Mechanism of action and research progress of vaccine adjuvants
10.12092/j.issn.1009-2501.2024.07.008
- VernacularTitle:疫苗佐剂的作用机制及研究进展
- Author:
Li ZHANG
1
;
Chang LU
;
Minghui AN
;
Mengmeng WANG
;
Xiaoyu ZONG
;
Lin YU
;
Zhuo-Ling RAN
;
Jing SONG
;
Huijie LI
;
Jian GONG
Author Information
1. 沈阳药科大学药物流行病与临床药物评价课题组,沈阳 110016,辽宁
- Keywords:
vaccines;
adjuvants;
mechanisms of action;
immunity
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2024;29(7):785-791
- CountryChina
- Language:Chinese
-
Abstract:
Vaccines are among the most effec-tive measures for preventing infectious diseases and play a crucial role in controlling the spread of these diseases.Adjuvants,serving as auxiliary com-ponents in vaccines,are indispensable in the vac-cine development process.Ideal adjuvants not only enhance the immune response,enabling the body to achieve optimal protective immunity but also play important roles in reducing the dosage of im-munogens and lowering vaccine production costs.To meet the demands of novel vaccines,many new types of adjuvants have been developed.However,there is still a lack of adjuvants that are safe,effec-tive,easy to prepare,highly pure,and suitable for a variety of vaccines in clinical settings.This article categorizes adjuvants and summarizes their mecha-nisms of action and characteristics,focusing on tra-ditional aluminum salt adjuvants and more modern lipid-based and nucleic acid-based adjuvants.The summary is based on a computer search of data-bases including PubMed,Embase,The Cochrane Li-brary,CNKI(China National Knowledge Infrastruc-ture),VIP Database,and Wanfang Database,using English search keywords such as Adjuvants,Vac-cine,Vaccine Adjuvant,aluminum salts,MF59,AS03,Toll-like receptor agonist,etc.,and corre-sponding Chinese search terms.The aim is to pro-vide references for the development and applica-tion of adjuvants.
