Application of single-cell multi-omics sequencing technology in the study of ischemic stroke

VernacularTitle:单细胞多组学测序技术在缺血性脑卒中研究中的应用
Author: Qian MENG ^{1
,

2} ; Yiwen WANG ; Na CUI ; Min BAI ; Le YANG ; Yi DING
Author Information

1. 西北大学生命科学学院,西安 710069,陕西
2. 空军军医大学西京医院药剂科,西安 710032,陕西
Keywords: ischemic stroke; single-cell sequenc-ing; single-cell multi-omics; biomarkers; precision medicine
From: Chinese Journal of Clinical Pharmacology and Therapeutics 2024;29(6):690-699
CountryChina
Language:Chinese
Abstract: Ischemic stroke is an acute cerebro-vascular disease with high disability and mortality,is the most common cause of death in China.De-spite years of research,there are still no biomark-ers for stroke,and the molecular mechanisms re-main largely unknown.In the past decade,single-cell sequencing technology,as a rapidly developing emerging technology,can conduct high-throughput sequencing of multiple omics including genome,transcriptome,epigenome and proteome at the level of a single cell,providing a new way to discov-er biomarkers and analyze pathological mecha-nisms.In this paper,the progress of single-cell multi-omics sequencing technology and its applica-tion in the discovery of biomarkers,pathological mechanisms and drug development of ischemic stroke are introduced in detail,in order to provide valuable reference for precision medicine of isch-emic stroke.