Surveillance of antimicrobial resistance in the First Affiliated Hospital of Xi'an Jiaotong University in 2022
10.16718/j.1009-7708.2024.05.012
- VernacularTitle:2022年西安交通大学第一附属医院细菌耐药性监测
- Author:
Xiaqin HE
1
;
Qingqing YANG
;
Xiaoqian WANG
;
Meng LIU
;
Wen LI
;
Xiaoyan ZENG
Author Information
1. 西安交通大学第一附属医院检验科,西安 710061
- Keywords:
bacterial resistance surveillance;
antimicrobial agent;
antimicrobial susceptibility testing;
methicillin-resistant S.aureus;
carbapenem-resistant Gram-negative bacilli
- From:
Chinese Journal of Infection and Chemotherapy
2024;24(5):581-587
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the distribution and antimicrobial resistance of clinical isolates in the First Affiliated Hospital of Xi'an Jiaotong University in 2022 for rational use of antibiotics in clinical practice.Methods Nonduplicate clinical isolates were collected from January 1,2022 to December 31,2022.Antimicrobial susceptibility testing was carried out using Kirby-Bauer method and automated systems.The data were analyzed using WHONET 5.6 software and interpreted according to the Clinical and Laboratory Standards Institute(CLSI)breakpoints(2021 Edition).Results Of the 8 638 clinical isolates,gram negative bacteria and gram positive bacteria accounted for 60.8％(5 253/8 638)and 39.2％(3 385/8 638),respectively.The prevalence of methicillin-resistant strains was 33.0％in S.aureus(MRSA),75.8％in S.epidermidis(MRSE),and 51.9％in other coagulase-negative Staphylococcus(MRCNS).No staphylococcal strains were found resistant to vancomycin.The prevalence of vancomycin-resistant E.faecium was 0.6％,and no vancomycin-resistant E.faecalis was found.E.faecalis strains showed higher resistance rate to linezolid(5.2％)than E.faecium(0.7％).The prevalence of carbapenem-resistant Enterobacterales(CRE)was 7.9％,specifically 12.1％for carbapenem-resistant K.pneumoniae(CRKP)and 1.6％for carbapenem-resistant E.coli(CREC).The prevalence of carbapenem-resistant P.aeruginosa(CRPA)and carbapenem-resistant A.baumannii(CRAB)was 30.9％and 77.0％,respectively.Conclusions Clinical microbiology laboratories should strengthen the collection and testing of clinical specimens from the sites of infection in order to improve pathogenic diagnosis and antimicrobial resistance surveillance.This is conducive to the rational use of antibiotics and reduce the further spread of multidrug-resistant bacteria.
