Cystatin C combined with prothrombin time for assessing the condition and outcome of patients with severe fever with thrombocytopenia syndrome
10.16718/j.1009-7708.2024.05.008
- VernacularTitle:胱抑素C联合凝血酶原时间评估发热伴血小板减少综合征患者病情及预后
- Author:
Guangshun SHI
1
;
Dongmei XIA
;
Liyu ZHU
Author Information
1. 安徽医科大学附属巢湖医院检验科,合肥 238000
- Keywords:
severe fever;
thrombocytopenia syndrome;
cystatin C;
outcome
- From:
Chinese Journal of Infection and Chemotherapy
2024;24(5):553-557
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of early cystatin C(Cys-C)combined with prothrombin time(PT)for assessing the severity and outcome of patients with severe fever with thrombocytopenia syndrome(SFTS).Methods The data of 101 patients with SFTS diagnosed and treated in Chaohu Hospital of Anhui Medical University from April 2021 to August 2023 were reviewed retrospectively.The patients were assigned to non-severe group or severe group according to the severity of the disease,and assigned to survivors group or deaths group according to the treatment outcome.The clinical manifestations and early laboratory test results were compared between groups.Logistic regression model was used to analyze the factors for predicting the outcome.The receiver operating characteristic(ROC)curve was used to evaluate the ability of Cys-C and PT levels alone and in combination to distinguish survivors from deaths.Results In the early stage,the patients in severe group and deaths group showed significantly higher levels of serum Cys-C,blood urea nitrogen(BUN),creatinine(Cr),uric acid(UA),PT,activated partial thromboplastin time(APTT),creatine kinase(CK)and creatine kinase MB(CKMB)but significantly lower lymphocyte count compared to the patients in the non-severe group and survivors group(P＜0.05).Multivariate binary Logistic regression analysis showed that age(OR=1.146,95％CI:1.036-1.267),PT(OR=2.643,95％CI:1.323-5.281),and Cys-C(OR=5.039,95％CI:1.548-16.395)were independent risk factors for the outcome of SFTS patients.Serum Cys-C was valuable in distinguishing survivors from deaths,the area under the ROC curve of which was 0.831.When Cys-C,PT and age were combined,the AUC was up to 0.930.Conclusions SFTS mainly occurs in farmers and elderly people.Serum PT and Cys-C levels at early stage can effectively predict the outcome of patients with SFTS.PT and Cys-C levels are expected to be biomarkers for distinguishing survivors from deaths.
