Changing resistance profiles of Proteus,Morganella and Providencia in hospitals across China:results from the CHINET Antimicrobial Resistance Surveillance Program,2015-2021
- VernacularTitle:2015-2021年CHINET临床分离变形杆菌属、摩根菌属和普罗威登菌属细菌耐药性变迁
- Author:
Yunmin XU
1
;
Xiaoxue DONG
;
Bin SHAN
;
Yang YANG
;
Fupin HU
;
Demei ZHU
;
Yingchun XU
;
Xiaojiang ZHANG
;
Ping JI
;
Fengbo ZHANG
;
Yi XIE
;
Mei KANG
;
Chuanqing WANG
;
Pan FU
;
Yuanhong XU
;
Ying HUANG
;
Ziyong SUN
;
Zhongju CHEN
;
Yuxing NI
;
Jingyong SUN
;
Yunzhuo CHU
;
Sufei TIAN
;
Zhidong HU
;
Jin LI
;
Yunsong YU
;
Jie LIN
;
Sufang GUO
;
Lianhua WEI
;
Fengmei ZOU
;
Hong ZHANG
;
Chun WANG
;
Yunjian HU
;
Xiaoman AI
;
Chao ZHUO
;
Danhong SU
;
Dawen GUO
;
Jinying ZHAO
;
Hua YU
;
Xiangning HUANG
;
Wen'en LIU
;
Yanming LI
;
Yan JIN
;
Chunhong SHAO
;
Xuesong XU
;
Chao YAN
;
Shanmei WANG
;
Yafei CHU
;
Lixia ZHANG
;
Juan MA
;
Shuping ZHOU
;
Yan ZHOU
;
Lei ZHU
;
Jinhua MENG
;
Fang DONG
;
Hongyan ZHENG
;
Fangfang HU
;
Han SHEN
;
Wanqing ZHOU
;
Wei JIA
;
Gang LI
;
Jinsong WU
;
Yuemei LU
;
Jihong LI
;
Jinju DUAN
;
Jianbang KANG
;
Xiaobo MA
;
Yanping ZHENG
;
Ruyi GUO
;
Yan ZHU
;
Yunsheng CHEN
;
Qing MENG
;
Shifu WANG
;
Xuefei HU
;
Jilu SHEN
;
Wenhui HUANG
;
Ruizhong WANG
;
Hua FANG
;
Bixia YU
;
Yong ZHAO
;
Ping GONG
;
Kaizhen WEN
;
Yirong ZHANG
;
Jiangshan LIU
;
Longfeng LIAO
;
Hongqin GU
;
Lin JIANG
;
Wen HE
;
Shunhong XUE
;
Jiao FENG
;
Chunlei YUE
Author Information
- Keywords: Proteus; Morganella; Providencia; carbapenem resistance; antimicrobial resistance surveillance
- From: Chinese Journal of Infection and Chemotherapy 2024;24(4):410-417
- CountryChina
- Language:Chinese
- Abstract: Objective To understand the changing distribution and antimicrobial resistance profiles of Proteus,Morganella and Providencia in hospitals across China from January 1,2015 to December 31,2021 in the CHINET Antimicrobial Resistance Surveillance Program.Methods Antimicrobial susceptibility testing was carried out following the unified CHINET protocol.The results were interpreted in accordance with the breakpoints in the 2021 Clinical & Laboratory Standards Institute(CLSI)M100(31 st Edition).Results A total of 32 433 Enterobacterales strains were isolated during the 7-year period,including 24 160 strains of Proteus,6 704 strains of Morganella,and 1 569 strains of Providencia.The overall number of these Enterobacterales isolates increased significantly over the 7-year period.The top 3 specimen source of these strains were urine,lower respiratory tract specimens,and wound secretions.Proteus,Morganella,and Providencia isolates showed lower resistance rates to amikacin,meropenem,cefoxitin,cefepime,cefoperazone-sulbactam,and piperacillin-tazobactam.For most of the antibiotics tested,less than 10％of the Proteus and Morganella strains were resistant,while less than 20％of the Providencia strains were resistant.The prevalence of carbapenem-resistant Enterobacterales(CRE)was 1.4％in Proteus isolates,1.9％in Morganella isolates,and 15.6％in Providencia isolates.Conclusions The overall number of clinical isolates of Proteus,Morganella and Providencia increased significantly in the 7-year period from 2015 to 2021.The prevalence of CRE strains also increased.More attention should be paid to antimicrobial resistance surveillance and rational antibiotic use so as to prevent the emergence and increase of antimicrobial resistance.
