Surveillance of antifungal resistance in clinical isolates of Candida spp.in East China Invasive Fungal Infection Group from 2018 to 2022
- VernacularTitle:2018-2022年华东地区临床分离念珠菌耐药性监测
- Author:
Dongjiang WANG
1
;
Wenjuan WU
;
Jian GUO
;
Min ZHANG
;
Huiping LIN
;
Feifei WAN
;
Xiaobo MA
;
Yueting LI
;
Jia LI
;
Huiqiong JIA
;
Lingbing ZENG
;
Xiuhai LU
;
Yan JIN
;
Jinfeng CAI
;
Wei LI
;
Zhimin BAI
;
Yongqin WU
;
Hui DING
;
Zhongxian LIAO
;
Gen LI
;
Hui ZHANG
;
Hongwei MENG
;
Changzi DENG
;
Feng CHEN
;
Na JIANG
;
Jie QIN
;
Guoping DONG
;
Jinghua ZHANG
;
Wei XI
;
Haomin ZHANG
;
Rong TANG
;
Li LI
;
Suzhen WANG
;
Fen PAN
;
Jing GAO
;
Lu JIANG
;
Hua FANG
;
Zhilan LI
;
Yiqun YUAN
;
Guoqing WANG
;
Yuanxia WANG
;
Liping WANG
Author Information
- Keywords: fungal resistance surveillance; Candida spp; invasive fungal infection; antifungal susceptibility testing; antifungal agent
- From: Chinese Journal of Infection and Chemotherapy 2024;24(4):402-409
- CountryChina
- Language:Chinese
- Abstract: Objective To monitor the antifungal resistance of clinical isolates of Candida spp.in the East China region.Methods MALDI-TOF MS or molecular methods were used to re-identify the strains collected from January 2018 to December 2022.Antifungal susceptibility testing was performed using the broth microdilution method.The susceptibility test results were interpreted according to the breakpoints of 2022 Clinical and Laboratory Standards Institute(CLSI)documents M27 M44s-Ed3 and M57s-Ed4.Results A total of 3 026 strains of Candida were collected,65.33％of which were isolated from sterile body sites,mainly from blood(38.86％)and pleural effusion/ascites(10.21％).The predominant species of Candida were Candida albicans(44.51％),followed by Candida parapsilosis complex(19.46％),Candida tropicalis(13.98％),Candida glabrata(10.34％),and other Candida species(0.79％).Candida albicans showed overall high susceptibility rates to the 10 antifungal drugs tested(the lowest rate being 93.62％).Only 2.97％of the strains showed dose-dependent susceptibility(SDD)to fluconazole.Candida parapsilosis complex had a SDD rate of 2.61％and a resistance rate of 9.42％to fluconazole,and susceptibility rates above 90％to other drugs.Candida glabrata had a SDD rate of 92.01％and a resistance rate of 7.99％to fluconazole,resistance rates of 32.27％and 48.24％to posaconazole and voriconazole non-wild-type strains(NWT),respectively,and susceptibility rates above 90％to other drugs.Candida tropicalis had resistance rates of 29.55％and 26.24％to fluconazole and voriconazole,respectively,resistance rates of 76.60％and 21.99％to posaconazole and echinocandins non-wild-type strains(NWT),and a resistance rate of 2.36％to echinocandins.Conclusions The prevalence and species distribution of Candida spp.in the East China region are consistent with previous domestic and international reports.Candida glabrata exhibits certain degree of resistance to fluconazole,while Candida tropicalis demonstrates higher resistance to triazole drugs.Additionally,echinocandins resistance has emerged in Candida albicans,Candida glabrata,Candida tropicalis,and Candida parapsilosis.
