Changing resistance profiles of Enterobacter isolates in hospitals across China:results from the CHINET Antimicrobial Resistance Surveillance Program,2015-2021
- VernacularTitle:2015-2021年CHINET临床分离肠杆菌属细菌耐药性变迁
- Author:
Shaozhen YAN
1
;
Ziyong SUN
;
Zhongju CHEN
;
Yang YANG
;
Fupin HU
;
Demei ZHU
;
Yi XIE
;
Mei KANG
;
Fengbo ZHANG
;
Ping JI
;
Zhidong HU
;
Jin LI
;
Sufang GUO
;
Han SHEN
;
Wanqing ZHOU
;
Yingchun XU
;
Xiaojiang ZHANG
;
Xuesong XU
;
Chao YAN
;
Chuanqing WANG
;
Pan FU
;
Wei JIA
;
Gang LI
;
Yuanhong XU
;
Ying HUANG
;
Dawen GUO
;
Jinying ZHAO
;
Wen'en LIU
;
Yanming LI
;
Hua YU
;
Xiangning HUANG
;
Bin SHAN
;
Yan DU
;
Shanmei WANG
;
Yafei CHU
;
Yuxing NI
;
Jingyong SUN
;
Yunsong YU
;
Jie LIN
;
Chao ZHUO
;
Danhong SU
;
Lianhua WEI
;
Fengmei ZOU
;
Yan JIN
;
Chunhong SHAO
;
Jihong LI
;
Lixia ZHANG
;
Juan MA
;
Yunzhuo CHU
;
Sufei TIAN
;
Jinju DUAN
;
Jianbang KANG
;
Ruizhong WANG
;
Hua FANG
;
Fangfang HU
;
Yunjian HU
;
Xiaoman AI
;
Fang DONG
;
Zhiyong LÜ
;
Hong ZHANG
;
Chun WANG
;
Yong ZHAO
;
Ping GONG
;
Lei ZHU
;
Jinhua MENG
;
Xiaobo MA
;
Yanping ZHENG
;
Jinsong WU
;
Yuemei LU
;
Ruyi GUO
;
Yan ZHU
;
Kaizhen WEN
;
Yirong ZHANG
;
Chunlei YUE
;
Jiangshan LIU
;
Wenhui HUANG
;
Shunhong XUE
;
Xuefei HU
;
Hongqin GU
;
Jiao FENG
;
Shuping ZHOU
;
Yan ZHOU
;
Yunsheng CHEN
;
Qing MENG
;
Bixia YU
;
Jilu SHEN
;
Rui DOU
;
Shifu WANG
;
Wen HE
;
Longfeng LIAO
;
Lin JIANG
Author Information
- Keywords: Enterobacter; Enterobacter cloacae; bacterial resistance surveillance; carbapenem-resistant
- From: Chinese Journal of Infection and Chemotherapy 2024;24(3):309-317
- CountryChina
- Language:Chinese
- Abstract: Objective To examine the changing antimicrobial resistance profile of Enterobacter spp.isolates in 53 hospitals across China from 2015 t0 2021.Methods The clinical isolates of Enterobacter spp.were collected from 53 hospitals across China during 2015-2021 and tested for antimicrobial susceptibility using Kirby-Bauer method or automated testing systems according to the CHINET unified protocol.The results were interpreted according to the breakpoints issued by the Clinical & Laboratory Standards Institute(CLSI)in 2021(M100 31st edition)and analyzed with WHONET 5.6 software.Results A total of 37 966 Enterobacter strains were isolated from 2015 to 2021.The proportion of Enterobacter isolates among all clinical isolates showed a fluctuating trend over the 7-year period,overall 2.5％in all clinical isolates amd 5.7％in Enterobacterale strains.The most frequently isolated Enterobacter species was Enterobacter cloacae,accounting for 93.7％(35 571/37 966).The strains were mainly isolated from respiratory specimens(44.4±4.6)％,followed by secretions/pus(16.4±2.3)％and urine(16.0±0.9)％.The strains from respiratory samples decreased slightly,while those from sterile body fluids increased over the 7-year period.The Enterobacter strains were mainly isolated from inpatients(92.9％),and only(7.1±0.8)％of the strains were isolated from outpatients and emergency patients.The patients in surgical wards contributed the highest number of isolates(24.4±2.9)％compared to the inpatients in any other departement.Overall,≤ 7.9％of the E.cloacae strains were resistant to amikacin,tigecycline,polymyxin B,imipenem or meropenem,while ≤5.6％of the Enterobacter asburiae strains were resistant to these antimicrobial agents.E.asburiae showed higher resistance rate to polymyxin B than E.cloacae(19.7％vs 3.9％).Overall,≤8.1％of the Enterobacter gergoviae strains were resistant to tigecycline,amikacin,meropenem,or imipenem,while 10.5％of these strains were resistant to polycolistin B.The overall prevalence of carbapenem-resistant Enterobacter was 10.0％over the 7-year period,but showing an upward trend.The resistance profiles of Enterobacter isolates varied with the department from which they were isolated and whether the patient is an adult or a child.The prevalence of carbapenem-resistant E.cloacae was the highest in the E.cloacae isolates from ICU patients.Conclusions The results of the CHINET Antimicrobial Resistance Surveillance Program indicate that the proportion of Enterobacter strains in all clinical isolates fluctuates slightly over the 7-year period from 2015 to 2021.The Enterobacter strains showed increasing resistance to multiple antimicrobial drugs,especially carbapenems over the 7-year period.
