Surveillance of bacterial resistance in tertiary hospitals across China:results of CHINET Antimicrobial Resistance Surveillance Program in 2022

Yan GUO; Fupin HU; Demei ZHU; Fu WANG; Xiaofei JIANG; Yingchun XU; Xiaojiang ZHANG; Fengbo ZHANG; Ping JI; Yi XIE; Yuling XIAO; Chuanqing WANG; Pan FU; Yuanhong XU; Ying HUANG; Ziyong SUN; Zhongju CHEN; Jingyong SUN; Qing CHEN; Yunzhuo CHU; Sufei TIAN; Zhidong HU; Jin LI; Yunsong YU; Jie LIN; Bin SHAN; Yunmin XU; Sufang GUO; Yanyan WANG; Lianhua WEI; Keke LI; Hong ZHANG; Fen PAN; Yunjian HU; Xiaoman AI; Chao ZHUO; Danhong SU; Dawen GUO; Jinying ZHAO; Hua YU; Xiangning HUANG; Wen'en LIU; Yanming LI; Yan JIN; Chunhong SHAO; Xuesong XU; Wei LI; Shanmei WANG; Yafei CHU; Lixia ZHANG; Juan MA; Shuping ZHOU; Yan ZHOU; Lei ZHU; Jinhua MENG; Fang DONG; Zhiyong LÜ; Fangfang HU; Han SHEN; Wanqing ZHOU; Wei JIA; Gang LI; Jinsong WU; Yuemei LU; Jihong LI; Qian SUN; Jinju DUAN; Jianbang KANG; Xiaobo MA; Yanqing ZHENG; Ruyi GUO; Yan ZHU; Yunsheng CHEN; Qing MENG; Shifu WANG; Xuefei HU; Wenhui HUANG; Juan LI; Quangui SHI; Juan YANG; Abulimiti REZIWAGULI; Lili HUANG; Xuejun SHAO; Xiaoyan REN; Dong LI; Qun ZHANG; Xue CHEN; Rihai LI; Jieli XU; Kaijie GAO; Lu XU; Lin LIN; Zhuo ZHANG; Jianlong LIU; Min FU; Yinghui GUO; Wenchao ZHANG; Zengguo WANG; Kai JIA; Yun XIA; Shan SUN; Huimin YANG; Yan MIAO; Mingming ZHOU; Shihai ZHANG; Hongjuan LIU; Nan CHEN; Chan LI; Jilu SHEN; Wanqi MEN; Peng WANG; Xiaowei ZHANG; Yanyan LIU; Yong AN

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Surveillance of bacterial resistance in tertiary hospitals across China:results of CHINET Antimicrobial Resistance Surveillance Program in 2022

VernacularTitle:2022年CHINET三级医院细菌耐药监测
Author: Yan GUO ¹ ; Fupin HU ; Demei ZHU ; Fu WANG ; Xiaofei JIANG ; Yingchun XU ; Xiaojiang ZHANG ; Fengbo ZHANG ; Ping JI ; Yi XIE ; Yuling XIAO ; Chuanqing WANG ; Pan FU ; Yuanhong XU ; Ying HUANG ; Ziyong SUN ; Zhongju CHEN ; Jingyong SUN ; Qing CHEN ; Yunzhuo CHU ; Sufei TIAN ; Zhidong HU ; Jin LI ; Yunsong YU ; Jie LIN ; Bin SHAN ; Yunmin XU ; Sufang GUO ; Yanyan WANG ; Lianhua WEI ; Keke LI ; Hong ZHANG ; Fen PAN ; Yunjian HU ; Xiaoman AI ; Chao ZHUO ; Danhong SU ; Dawen GUO ; Jinying ZHAO ; Hua YU ; Xiangning HUANG ; Wen'en LIU ; Yanming LI ; Yan JIN ; Chunhong SHAO ; Xuesong XU ; Wei LI ; Shanmei WANG ; Yafei CHU ; Lixia ZHANG ; Juan MA ; Shuping ZHOU ; Yan ZHOU ; Lei ZHU ; Jinhua MENG ; Fang DONG ; Zhiyong LÜ ; Fangfang HU ; Han SHEN ; Wanqing ZHOU ; Wei JIA ; Gang LI ; Jinsong WU ; Yuemei LU ; Jihong LI ; Qian SUN ; Jinju DUAN ; Jianbang KANG ; Xiaobo MA ; Yanqing ZHENG ; Ruyi GUO ; Yan ZHU ; Yunsheng CHEN ; Qing MENG ; Shifu WANG ; Xuefei HU ; Wenhui HUANG ; Juan LI ; Quangui SHI ; Juan YANG ; Abulimiti REZIWAGULI ; Lili HUANG ; Xuejun SHAO ; Xiaoyan REN ; Dong LI ; Qun ZHANG ; Xue CHEN ; Rihai LI ; Jieli XU ; Kaijie GAO ; Lu XU ; Lin LIN ; Zhuo ZHANG ; Jianlong LIU ; Min FU ; Yinghui GUO ; Wenchao ZHANG ; Zengguo WANG ; Kai JIA ; Yun XIA ; Shan SUN ; Huimin YANG ; Yan MIAO ; Mingming ZHOU ; Shihai ZHANG ; Hongjuan LIU ; Nan CHEN ; Chan LI ; Jilu SHEN ; Wanqi MEN ; Peng WANG ; Xiaowei ZHANG ; Yanyan LIU ; Yong AN
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1. 复旦大学附属华山医院抗生素研究所,国家卫健委抗生素临床药理重点实验室,上海 200040
Keywords: tertiary hospital; antimicrobial resistance surveillance; antimicrobial susceptibility testing; carbapenem-resistant gram-negative bacilli
From: Chinese Journal of Infection and Chemotherapy 2024;24(3):277-286
CountryChina
Language:Chinese
Abstract: Objective To monitor the susceptibility of clinical isolates to antimicrobial agents in tertiary hospitals in major regions of China in 2022.Methods Clinical isolates from 58 hospitals in China were tested for antimicrobial susceptibility using a unified protocol based on disc diffusion method or automated testing systems.Results were interpreted using the 2022 Clinical &Laboratory Standards Institute(CLSI)breakpoints.Results A total of 318 013 clinical isolates were collected from January 1,2022 to December 31,2022,of which 29.5％were gram-positive and 70.5％were gram-negative.The prevalence of methicillin-resistant strains in Staphylococcus aureus,Staphylococcus epidermidis and other coagulase-negative Staphylococcus species(excluding Staphylococcus pseudintermedius and Staphylococcus schleiferi)was 28.3％,76.7％and 77.9％,respectively.Overall,94.0％of MRSA strains were susceptible to trimethoprim-sulfamethoxazole and 90.8％of MRSE strains were susceptible to rifampicin.No vancomycin-resistant strains were found.Enterococcus faecalis showed significantly lower resistance rates to most antimicrobial agents tested than Enterococcus faecium.A few vancomycin-resistant strains were identified in both E.faecalis and E.faecium.The prevalence of penicillin-susceptible Streptococcus pneumoniae was 94.2％in the isolates from children and 95.7％in the isolates from adults.The resistance rate to carbapenems was lower than 13.1％in most Enterobacterales species except for Klebsiella,21.7％-23.1％of which were resistant to carbapenems.Most Enterobacterales isolates were highly susceptible to tigecycline,colistin and polymyxin B,with resistance rates ranging from 0.1％to 13.3％.The prevalence of meropenem-resistant strains decreased from 23.5％in 2019 to 18.0％in 2022 in Pseudomonas aeruginosa,and decreased from 79.0％in 2019 to 72.5％in 2022 in Acinetobacter baumannii.Conclusions The resistance of clinical isolates to the commonly used antimicrobial agents is still increasing in tertiary hospitals.However,the prevalence of important carbapenem-resistant organisms such as carbapenem-resistant K.pneumoniae,P.aeruginosa,and A.baumannii showed a downward trend in recent years.This finding suggests that the strategy of combining antimicrobial resistance surveillance with multidisciplinary concerted action works well in curbing the spread of resistant bacteria.