Cardiac CT angiography for left atrial appendage closure:Animal experiment
10.13929/j.issn.1672-8475.2024.11.009
- VernacularTitle:心脏CT血管造影用于左心耳封堵术:动物实验
- Author:
Ziyi ZHANG
1
;
Binbin ZHANG
;
Yingjian CUI
;
He HAN
;
Zhixiao XUE
Author Information
1. 天津医科大学生物医学工程与技术学院,天津 300071
- Keywords:
dogs;
atrial fibrillation;
atrial appendage;
occlude;
tomography,X-ray computed
- From:
Chinese Journal of Interventional Imaging and Therapy
2024;21(11):690-695
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the value of cardiac CT angiography(CCTA)for left atrial appendage closure(LAAC).Methods Twelve Labradors were enrolled and underwent LAAC.CCTA examinations were performed before and 7,45 and 90 days after LAAC,and the left atrial appendage(LAA)parameters before and post LAAC occluder compression ratio were recorded.Ninety days after LAAC,the dogs were euthanized for gross anatomical observation,micro CT imaging and pathological examination,and the value of CCTA for LAAC was analyzed.Results Based on CCTA before LAAC,LAA opening depth was(18.8±2.6)mm,the minimum diameter was(16.3±2.0)mm and the maximum diameter was(22.6±3.2)mm,so 28 mm diameter occluders were selected for LAAC.Seven,45 and 90 days after LAAC,no displacement of occluder,thrombi nor device leakage was found on CCTA,while no significant difference of compression ratio was found among different time points(P＞0.05),nor between those measured with CCTA and micro CT 90 days after LAAC(P＞0.05).Ninety days after LAAC,gross dissection revealed complete endothelialization of occlude in 11 dogs and incomplete endothelialization in 1 dog.Pathological examination showed that collagen fibers arranged neatly,with endothelial cells covering the surface,and no inflammatory cell infiltration was observed.Conclusion CCTA could be used to observe LAA and surrounding structures before LAAC,hence guiding to select appropriate occluder,evaluate occlusion effect and monitor complications of LAAC in dogs.
