Meta-analysis on the safety and efficacy of very early mobilization intervention in patients with acute cerebral stroke
10.3760/cma.j.cn115682-20230407-01367
- VernacularTitle:急性脑卒中患者超早期活动干预安全性和有效性的Meta分析
- Author:
Gonglin XU
1
;
Chengcheng LI
;
Ruiying MA
Author Information
1. 首都医科大学护理学院，北京 100069
- Keywords:
Meta-analysis;
Cerebral infarction;
Rehabilitation;
Acute;
Very early mobilization
- From:
Chinese Journal of Modern Nursing
2023;29(31):4261-4269
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the safety and efficacy of very early mobilization intervention in patients with acute cerebral stroke through a Meta-analysis.Methods:Randomized controlled trials (RCTs) investigating the efficacy and safety of very early mobilization intervention in acute cerebral stroke patients were searched in databases including PubMed, Cochrane Library, Embase, CNKI, Wanfang, VIP and SinoMed up until January 23, 2023. Two researchers independently screened the literature, extracted data, and assessed the quality of the included studies based on inclusion and exclusion criteria. Analysis was performed using RevMan 5.3.Results:A total of 13 studies involving 3 202 acute cerebral stroke patients were included. The Meta-analysis revealed that compared with conventional nursing methods, very early mobilization intervention effectively reduced the incidence of post-stroke complications [ RR=0.59, 95% CI (0.46, 0.75), P<0.001], enhanced patients' daily living abilities [ MD=6.63, 95% CI (2.99, 10.27), P<0.001], and shortened the length of hospital stay [ MD=-2.46, 95% CI (-3.86, -1.05), P<0.001]. The intervention did not increase the rates of mortality [ RR=1.11, 95% CI (0.85, 1.45), P>0.05], adverse events [ RR=0.85, 95% CI (0.60, 1.20), P>0.05], or disability [ RR=0.94, 95% CI (0.76, 1.15), P>0.05] in acute cerebral stroke patients. Subgroup analysis on the initiation time and frequency of the intervention showed a statistically significant reduction in mortality rate in the 24-72 h subgroup ( P<0.05), while no significant difference was found in the 0-24 h subgroup ( P>0.05). Both subgroups with activity frequencies of ≥1 time/day and ≥2 times/day showed significant improvements in daily living abilities compared to conventional care ( P<0.05), whereas no significant difference was found in the subgroup with uncertain daily activity frequency ( P>0.05) . Conclusions:Very early mobilization intervention can safely and effectively reduce the incidence of post-stroke complications in patients with acute cerebral stroke, improve daily living abilities, and shorten the length of hospital stay.
