A Case of Clomipramine-Induced Chronic Dilated Cardiomyopathy.
10.4070/kcj.1998.28.8.1393
- Author:
Eung Ju KIM
;
Chang Gyu PARK
;
Sung Hee SHIN
;
Jin Won KIM
;
Jang Wook SOHN
;
Chang Don KANG
;
Chang Won CHOI
;
Byung Hoe KIM
;
Hyun Chul KIM
;
Seung Jin LEE
;
Eun Mi LEE
;
Jung Chun AHN
;
Hong Seog SEO
;
Dong Joo OH
;
Young Moo RO
- Publication Type:Case Report
- Keywords:
Dilated cardiomyopathy;
Tricyclic antidepressant drug;
Clomipramine
- MeSH:
Adult;
Antidepressive Agents, Tricyclic;
Bacterial Infections;
Cardiomyopathies;
Cardiomyopathy, Dilated*;
Clomipramine;
Cocaine-Related Disorders;
Dilatation;
Humans;
Obsessive-Compulsive Disorder;
Thiamine Deficiency
- From:Korean Circulation Journal
1998;28(8):1393-1397
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Dilated cardiomyopathy is a primary myocardial disease characterized by ventricular dilatation and impaired ventricular contractility. The etiology of dilated cardiomyopathy has not been known yet, but toxin such as alcohol, thiamine deficiency, endocrine disorder, viral or bacterial infection, hereditary disorder, and muscular dystrophy may be related to dilated cardiomyopathy. Cocaine abuse and anticancer drugs (especially doxorubicin) were reported as the causes of drugs of dilated cardiomyopathy also. Recently we experinced a case of dilated cardiomyopathy in 30 years old man who developed dilated cardiomyopathy on chronic clomipramine (one of trcyclic antidepressant drugs) treatment for a obsessive-compulsive disorder. He became asymptomatic and normalization of left ventricular diameters and function was evidenced echocardiographically after withdrawal of the drug. The possible association of cardiomyopathy and tricyclic antidepressant drugs and possibility of functional improvement after tricyclic antidepressant drugs withdrawal should be kept in mind.
