MRI combined with serum carbohydrate antigen 125 and human epididymis protein 4 for differential diagnosis of type Ⅰ and Ⅱ epithelial ovarian cancers
10.13929/j.issn.1672-8475.2024.09.009
- VernacularTitle:MRI联合糖类抗原125及人附睾蛋白4鉴别诊断Ⅰ型与Ⅱ型上皮性卵巢癌
- Author:
Xuehuan ZHAO
1
;
Qiumei LIU
;
Jie DING
;
Zhenzhen WANG
;
Jianli LIU
;
Yinghui LIU
Author Information
1. 菏泽市立医院CT室,山东 菏泽 274000
- Keywords:
ovarian neoplasms;
biomarkers,tumor;
magnetic resonance imaging
- From:
Chinese Journal of Interventional Imaging and Therapy
2024;21(9):549-552
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the value of MRI combined with serum carbohydrate antigen 125(CA125)and human epididymis protein 4(HE4)for differential diagnosis of type Ⅰ and Ⅱ epithelial ovarian cancers(EOC).Methods Totally 87 EOC patients were retrospectively enrolled.According to pathology,35 cases of type Ⅰ EOC were taken as type Ⅰ group,while 52 cases of type Ⅱ EOC were taken as type Ⅱ group.Conventional MRI manifestations and apparent diffusion coefficient(ADC)value of lesions,as well as CA125 and HE4 were compared between groups,and their efficacy for differential diagnosis of type Ⅰ and Ⅱ EOC were analyzed.Results Significant differences of conventional MRI manifestations of lesions,including composition,mural nodules,peritoneal diffusion and lymph node metastasis,of ADC value of lesions,also of patients'CA125 and HE4 were found between groups(all P＜0.05).The area under the curve(AUC)of conventional MRI manifestations and ADC value of lesions,patients'CA125 and HE4 for distinguishing typeⅠ and type Ⅱ EOC was 0.694,0.730,0.670 and 0.708,respectively,while of the combination of the above four was 0.865,higher than that of each one alone(Z=3.008,2.138,3.005,2.746,all P＜0.05).Conclusion MRI combined with CA125 and HE4 was helpful for differential diagnosis of type Ⅰ and Ⅱ EOC.
