Safety of injection methods for low molecular weight heparin: an overview of systematic review
10.3760/cma.j.cn115682-20230206-00376
- VernacularTitle:低分子肝素注射方法安全性的系统评价再评价
- Author:
Ranxun AN
1
;
Jianhua SUN
;
Yuan XU
;
Lei WANG
;
Haibo DENG
;
Xiaojie WANG
;
Yu WANG
;
Liyun ZHU
;
Qiaodan LU
;
Xinyi ZHOU
;
Yufen MA
Author Information
1. 中国医学科学院北京协和医学院北京协和医院护理部，北京 100730
- Keywords:
Low molecular weight heparin;
Injection method;
Safety;
Overview of systematic review;
Evidence-based nursing
- From:
Chinese Journal of Modern Nursing
2023;29(29):4018-4025
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To conduct an overview of systematic review of the safety of low molecular weight heparin (LMWH) injection methods.Methods:The systematic review of the safety of LMWH injection method was searched through computer on China National Knowledge Infrastructure, WanFang Data, China Biomedical Literature Service System, China Science and Technology Journal Database, PubMed, Embase, CINAHL, The Cochrane Library, Joanna Briggs Institute (JBI) System Review and Evidence Application Report Database, and Campbell Collaborative Collaboration. The search period was from the establishment of the database to December 31, 2022. AMSTAR 2 and ROBIS software were used for quality evaluation of system reviews, and the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) system was used for evidence grading.Results:A total of 10 systematic reviews were included. AMSTAR 2 software evaluation showed that the methodological quality of 1 article was low and 9 articles were extremely low. The ROBIS software evaluation showed that the overall bias risk of 3 system atic reviews was low, and 7 reviews were high. The GRADE system was used to grade 47 pieces of evidence from 10 systematic reviews, including 4 pieces of medium-quality evidence, 34 pieces of low-quality evidence, and 9 pieces of extremely low-quality evidence.Conclusions:Slow injection, abdominal injection, vertical injection, and local compression for 5 minutes after injection may be beneficial for the safety of LMWH subcutaneous injection. However, high-quality original studies targeting different subgroups and injection methods still need to be conducted on a large sample to support the conclusions.
