Correlations of conventional ultrasound and contrast-enhanced ultrasound features with Ki-67 expression level of intrahepatic cholangiocarcinoma
10.13929/j.issn.1672-8475.2024.07.012
- VernacularTitle:常规超声及超声造影特征与肝内胆管癌表达Ki-67水平的相关性
- Author:
Zheyuan ZHANG
1
;
Huabin ZHANG
;
Zhiyong BAI
;
Qingting TAN
;
Lei ZHANG
;
Xia XIE
;
Xiuming WANG
Author Information
1. 清华大学附属北京清华长庚医院超声科 清华大学临床医学院,北京 102218
- Keywords:
cholangiocarcinoma;
ultrasonography;
contrast media;
Ki-67 antigen
- From:
Chinese Journal of Interventional Imaging and Therapy
2024;21(7):436-439
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the correlations of conventional ultrasound and contrast-enhanced ultrasound(CEUS)features with expression level of Ki-67 of intrahepatic cholangiocarcinoma(ICC).Methods A total of 77 patients with pathologically confirmed ICC were retrospectively enrolled.According to the expression level of Ki-67 of target lesions,the patients were divided into high expression group(Ki-67≥20%,n=53)and low expression group(Ki-67＜20%,n=24).The features showed on conventional ultrasound and CEUS were compared between groups,and the variables being significantly different were analyzed with multivariate logistic regression to select ultrasonic features being correlated with Ki-67 expression level of ICC.Results The mean maximum diameter of ICC in high expression group was larger than that in low expression group([6.2±2.0]cm vs.[5.2±1.9]cm,P=0.041),and the percentage of ICC with maximum diameter>5 cm in high expression group was higher than that in low expression group(66.04%vs.33.33%,P=0.007).No significant difference of the lesions shape,border nor the internal echogenicity showed on conventional ultrasound was found between groups(all P＞0.05).The percentage of ICC with peripheral rim enhancement and enlargement after enhancement in high expression group were both higher than those in low expression group(both P＜0.05),but no significant difference of the enhancement pattern,the presence or absence of non-enhance area within the lesion nor the peak intensity of lesions was found between groups(all P＞0.05).The maximum diameter larger than 5 cm(OR=5.612,P=0.004)and peripheral rim enhancement(OR=3.880,P=0.025)were both independent factors for predicting high Ki-67 expression level of ICC.Conclusion ICC with the maximum diameter larger than 5 cm and peripheral rim enhancement on CEUS might indicate high expression level of Ki-67,which was helpful for clinical treatment decisions.
