Factors influencing sarcopenia in patients with chronic obstructive pulmonary disease: a Meta-analysis
10.3760/cma.j.cn115682-20230529-02130
- VernacularTitle:慢性阻塞性肺疾病患者并发肌少症影响因素的Meta分析
- Author:
Xiaohui SUN
1
;
Ting TANG
;
Chen WANG
;
Mingye QU
;
Yuanyuan CHEN
;
Kouying LIU
Author Information
1. 南京医科大学护理学院，南京 210000
- Keywords:
Pulmonary disease, chronic obstructive;
Sarcopenia;
Influencing factors;
Meta-analysis
- From:
Chinese Journal of Modern Nursing
2023;29(29):3936-3942
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the influencing factors of chronic obstructive pulmonary disease (COPD) complicated with sarcopenia by Meta-analysis, so as to provide evidence-based basis for early prevention of sarcopenia.Methods:The literature on the influencing factors of COPD patients with sarcopenia was searched on China National Knowledge Infrastructure, VIP, WanFang Data, PubMed, Web of Science, Cochrane Library, CINAHL, and Embase. The search period was from database establishment to April 3, 2023. Stata 17.0 software was used for meta-analysis.Results:A total of 14 articles were included, including 13 cross-sectional studies and one cohort study. There were 1 921 COPD patients, of which 591 were complicated with sarcopenia. A total of 8 influencing factors were extracted. The analysis results showed that age [ OR=1.09, 95% confidence interval ( CI) : 1.06-1.12, P<0.01], the Global for Chronic Obstructive Lung Disease (GOLD) grade ( OR=8.83, 95% CI: 1.88-41.53), P<0.01), modified Medical Research Council Dyspnea Scale (mMRC) score ( OR=2.10, 95% CI: 1.30-3.40, P<0.01), BMI ( OR=0.65, 95% CI: 0.56-0.76, P<0.01), forced expiratory volume in the first second/forced vital capacity (FEV 1/FVC) ( OR=0.95, 95% CI: 0.92-0.99, P<0.01) were influencing factors for COPD patients with sarcopenia, while smoking, gender and TNF-α were not influencing factors for COPD patients with sarcopenia. Conclusions:Age, GOLD grade, mMRC score, BMI and FEV 1/FVC were influencing factors for COPD complicated with sarcopenia. Clinical medical and nursing staffs should pay attention to key populations and conduct early screening and prevention of sarcopenia.
