Mechanism and clinical study of cardiac contractility modulation for heart failure

VernacularTitle:心脏收缩力调节器用于心力衰竭的机制和临床研究
Author: Qun LU ¹ ; Xiao LIANG ; Ling BAI ; Dan-Jun ZHU ; Xiao-Lin XUE ; Ke HAN
Author Information

1. 西安交通大学第一附属医院心血管内科,陕西西安 710061
Keywords: Cardiac contractility modulation; Heart failure with reduced ejection fraction; Mechanism studies; Clinical research
From: Chinese Journal of Interventional Cardiology 2024;32(8):457-462
CountryChina
Language:Chinese
Abstract: Cardiac contractility modulation(CCM),as a new implantable electronic therapy device for treating chronic heart failure with reduced ejection fraction(HFrEF),has rapidly become a hot topic in the cardiovascular field due to its ability to enhance ventricular myocardial contractility,improve patients'symptoms and signs,cardiac function indexes and even long-term prognosis.This article reviews the mechanism and clinical studies of CCM in treating HFrEF,and based on its mechanism and signal transduction algorithm,further analyzes and prospects its efficacy in patients with heart failure with preserved ejection fraction,cardiac resynchronization therapy non-response,and HFrEF with concomitant atrial fibrillation,aiming to promote CCM to meet the needs of more diverse clinical situations in heart failure patients.