Study on the safety and efficacy of novel portable extracorporeal membrane oxygenation in animal experiments in vivo
10.3969/j.issn.1004-8812.2024.08.005
- VernacularTitle:新型便携式体外膜肺氧合动物实验在体安全性和有效性研究
- Author:
Meng-En ZHAI
1
;
Jian-Chao LUO
;
Lin-He LU
;
Yu-Chao REN
;
Ping JIN
;
Zhen-Hua LIU
;
Jian YANG
;
Zhen-Xiao JIN
;
Jin-Cheng LIU
;
Yang LIU
Author Information
1. 中国人民解放军空军军医大学第一附属医院心血管外科,陕西西安 710032
- Keywords:
Portable extracorporeal membrane oxygenation;
Xijing Advanced Life Support System JC-Ⅲ;
Large animal experiments;
Safety;
Efficacy
- From:
Chinese Journal of Interventional Cardiology
2024;32(8):447-450
- CountryChina
- Language:Chinese
-
Abstract:
Objective To verify the safety and efficacy of a new portable extracorporeal membrane oxygenation(ECMO)system(Xijing Advanced Life Support System JC-Ⅲ)in large animals.Methods A total of 10 healthy small fat-tail sheep underwent veno-arterial extracorporeal membrane oxygenation(VA-ECMO)support by carotid arterial-jugular catheterization to evaluate the performance of the JC-Ⅲ ECMO system.Systemic anticoagulation was achieved by continuous infusion of heparin.Active coagulation time(ACT)was recorded every 2 hours during the experiment,and the ACT was maintained between 200-250 s.Centrifugal pump speed is set at 3 000-3 500 r/min.The changes of hemoglobin,blood cell counts,hematocrit,liver and kidney function were monitored before and 24 h after ECMO initiation,respectively.After the experiment,the pump and oxygenator were dissected to probe the thrombosis.Results The success rate of VA-ECMO operation was 100％,and there was no hemolysis,pump thrombosis and oxygenator thrombosis after 24 h of ECMO.Before and after the operation,there were no significant changes in indicators such as hemoglobin content,white blood cell counts,platelet counts,alanine aminotransferase concentration,aspartate aminotransferase concentration,urea,creatinine,high-sensitivity troponin Ⅰ,and N-terminal pro-brain natriuretic peptide(all P＞0.05).Conclusions This in vivo study confirms that Xijing Advanced Life support System JC-Ⅲ is safe and effective.
