Effect of swimming exercise on lipid metabolism in NAFLD mice based on lipidomics
- VernacularTitle:基于脂质组学探究游泳运动对NAFLD小鼠脂质代谢的改善作用
- Author:
Yan LUO
1
;
Ping DENG
;
Meng-Yan CHEN
;
Jia XIE
;
Li TIAN
;
Hui-Feng PI
Author Information
- Keywords: NAFLD; swimming exercise; lipidomics; lipid metabolism
- From: Journal of Regional Anatomy and Operative Surgery 2024;33(12):1027-1033
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the regulatory effect of swimming exercise(SE)on lipid metabolism in nonalcoholic fatty liver disease(NAFLD)mice.Methods A total of 27 C57BL/6J mice were divided into the control group(normal diet),high fat diet(HFD)group and HFD+SE group,with 9 mice in each group.Twelve weeks later,liver tissues were collected for untargeted lipidomics detection by LC-MS.Dimensional statistical analysis of lipidomics profiles was carried out by constructing OPLS-DA model,and combined with the t-test,the lipids with OPLS-DA VIP>1,P<0.05 were screened out from all samples as significantly different lipids.Results There were 81 different lipids between HFD group and the control group;and there were 27 different lipids between HFD+SE group and HFD group.The different lipids mainly belong to glycerides,glycerophospholipids and sphingomyelins.Conclusion Lipid metabolism profile of NAFLD mice has been changed,and swimming exercise can improve lipid metabolism of NAFLD mice.
