Research progress of heme oxygenase-1 in neurodegenerative diseases
- VernacularTitle:血红素加氧酶-1与神经退行性疾病的研究进展
- Author:
Shuai-Tian YANG
1
;
Jun-Yao FEI
;
Nuo XU
;
Yong-Kang YIN
;
Yu-Jia JIANG
;
Zheng NIE
Author Information
- Keywords: heme oxygenase-1; neurodegenerative diseases; biological characteristics; Alzheimer's disease; Parkinson's disease; amyotrophic lateral sclerosis
- From: Journal of Regional Anatomy and Operative Surgery 2024;33(5):460-463
- CountryChina
- Language:Chinese
- Abstract: Heme oxygenase-1(HO-1)is an inducible heme oxygenase and a catalytic enzyme for heme decomposition reactions,which can catalyze the heme decomposition into CO,biliverdin and Fe2+.HO-1 and its metabolites have anti-inflammatory,antioxidant and anti-apoptotic effects in human body,and play an important role in neurodegenerative diseases such as Alzheimer's disease,Parkinson's disease,amyotrophic lateral sclerosis,and Huntington's disease.This article will review the production,distribution,and gene structure of HO-1,the biological characteristics of its metabolites,and the role and mechanism of HO-1 in neurodegenerative diseases,in order to provide a theoretical basis for the clinical application of HO-1.
