Effects of ginkgo biloba diterpene lactone glucosamine injection combined with Tui Na techniques on endothelin-1, S100β, and hemorheology in patients with acute cerebral infarction
10.3760/cma.j.cn341190-20240306-00229
- VernacularTitle:银杏二萜内酯葡胺注射液联合调督舒筋手法对急性脑梗死患者ET-1、S100β及血液流变学的影响
- Author:
Jingyi WANG
1
;
Ya ZHENG
;
Haiyan SHI
Author Information
1. 宁波市康复医院药学科，宁波 315040
- Keywords:
Brain infarction;
Bilobalides;
Musculoskeletal manipulations;
Receptor, endothelin A;
Hemorheology;
Treatment outcome
- From:
Chinese Journal of Primary Medicine and Pharmacy
2024;31(11):1693-1698
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of ginkgo biloba diterpene lactone glucosamine injection combined with Tui Na techniques on endothelin-1, S100β, and hemorheology in patients with acute cerebral infarction.Methods:The clinical data of 100 patients with acute cerebral infarction admitted to Ningbo Rehabilitation Hospital from March 2022 to September 2023 were retrospectively analyzed. These patients were assigned to an observation group and a control group, with 50 patients in each group, based on the treatment methods used. The control group received treatment with ginkgo biloba diterpene lactone glucosamine injection, while the observation group received the same treatment along with treatment with Tui Na techniques for regulating and relaxing muscles. Both groups underwent treatment for 4 weeks. Clinical efficacy, serum endothelin-1 and S100β protein levels, changes in hemorheology, and the incidence of adverse reactions were compared between the two groups. Results:After 4 weeks of treatment, the Trunk Impairment Scale (TIS) scores in the observation group were lower than those in the control group ( t = 14.96, 45.82, 430.07, 331.30, 670.82, 195.02, all P < 0.05). The serum levels of endothelin-1 and S100β protein in the observation group were (45.45 ± 4.28) μmoL/L and (0.56 ± 0.12) μg/L, respectively, which were significantly lower than those in the control group [(53.52 ± 5.78) μmoL/L, (0.78 ± 0.16) μg/L, t = 7.93, 7.78, both P < 0.05]. The whole blood viscosity, plasma viscosity, and fibrinogen levels in the observation group were (4.56 ± 0.45) mPa·s, (1.62 ± 0.41) mPa·s, and (3.69 ± 0.42) g/L, respectively, which were significantly lower than those in the control group [(5.26 ± 0.97) mPa·s, (1.98 ± 0.46) mPa·s, (4.08 ± 0.49) g/L, t = 4.63, 4.13, 4.27, all P < 0.05]. The incidence of adverse reactions in the observation group was significantly lower than that in the control group [6% (3/50) vs. 32% (16/50), χ2 = 10.98, P < 0.05]. Conclusion:The combination of ginkgo biloba diterpene lactone injection and Tui Na techniques significantly enhances clinical efficacy in patients with acute cerebral infarction. This combined therapy reduces serum levels of endothelin-1 and S100β protein, improves hemorheological parameters, and leads to a lower incidence of adverse reactions compared with treatment with ginkgo biloba diterpene lactone glucosamine injection alone.
