Research progress on the effect of hypoxia-inducible factor on vascular calcification in chronic kidney disease under hypoxic conditions
10.3760/cma.j.cn341190-20240206-00161
- VernacularTitle:低氧状态下HIF对慢性肾脏病血管钙化影响的研究进展
- Author:
Rong DAI
1
;
Jiamei DI
Author Information
1. 蚌埠医科大学研究生院，蚌埠 232061
- Keywords:
Hypoxia;
Nephrosis;
Chronic disease;
Vascular calcification;
Myocytes, smooth muscle
- From:
Chinese Journal of Primary Medicine and Pharmacy
2024;31(8):1270-1274
- CountryChina
- Language:Chinese
-
Abstract:
Patients with chronic kidney disease are in a state of hypoxia for a long time. Hypoxia-inducible factor, as a key regulator of the hypoxia response, can regulate the expression and secretion of various osteogenic markers through multiple signaling pathways, promote osteogenic differentiation of vascular smooth muscle cells,and participate in the formation of vascular calcification. It can also contribute to vascular calcification by inducing oxidative stress, promoting autophagy, and influencing the glycolysis pathway. This involvement significantly increases the morbidity and mortality associated with cardiovascular events in patients with chronic kidney disease. This article reviews the research related to the mechanisms of vascular calcification in patients with chronic kidney disease induced by hypoxia-inducible factor under hypoxic conditions, as well as the possible treatments for this disease.
