Clinical efficacy of ciprofol in modified electroconvulsive therapy for the treatment of major depressive disorder in patients
10.3760/cma.j.cn341190-20230331-00242
- VernacularTitle:环泊酚在重度抑郁症患者无抽搐电休克治疗中的效果观察
- Author:
Pengjie KONG
1
;
Jieping LYU
Author Information
1. 山西中医药大学附属医院麻醉科，太原 030024
- Keywords:
Depressive disorder;
Electroshock;
Heart rate;
Arterial pressure;
Oximetry;
Ciprofol
- From:
Chinese Journal of Primary Medicine and Pharmacy
2024;31(8):1121-1125
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical efficacy of ciprofol in modified electroconvulsive therapy for the treatment of major depressive disorder in patients.Methods:A total of 60 patients with major depressive disorder who received modified electroconvulsive therapy at the Department of Psychiatry, First Hospital of Shanxi Medical University, from November 2022 to March 2023 were included in this study. They were aged 18-60 years and classified as American Society of Anesthesiologists grades Ⅰ-Ⅱ. The patient cohort consisted of 31 males and 29 females, with a body mass index of 18-30 kg/m2. The disease duration varied from 3 months to 5 years. This study was designed as a prospective study. All included patients were assigned to observation (ciprofol + succinylcholine) and control (propofol + succinylcholine) using the digital number table method. Vital signs, including heart rate, mean arterial pressure, and blood oxygen saturation, were compared between the two groups at four time points: before anesthesia (T 0), after anesthesia (T 1), immediately after electroconvulsive therapy (T 2), and after the completion of electroconvulsive therapy (T 3). The time to recover spontaneous breathing (from intravenous injection of succinylcholine to the onset of spontaneous breathing), the time to recover consciousness (from intravenous injection of ciprofol/propofol to the onset of consciousness), the need for additional anesthetic drugs, the use of vasoactive medications, and the occurrence of adverse reactions were recorded in each group. Results:Compared with T 0, both groups exhibited a decrease in mean arterial pressure at T 1 and an increase at T 2 and T 3. The differences in mean arterial pressure between T 1, T 2, T 3, and T 0 were statistically significant [observation group: T 0: (84.11 ± 8.69) mmHg (1 mmHg = 0.133 kPa), T 1: (78.18 ± 8.39) mmHg, T 2: (99.28 ± 12.42) mmHg, T 3: (87.31 ± 8.66) mmHg; control group: T 0: (86.33 ± 10.99) mmHg, T 1: (75.93 ± 9.51) mmHg, T 2: (100 ± 13.3) mmHg, T 3: (93.47 ± 12.27) mmHg, all P < 0.05]. There was no statistically significant difference in heart rate at different time points between the two groups (all P > 0.05). The change in mean arterial pressure from T 0 to T 1 in the observation group was smaller than that in the control group during the same period. The change in mean arterial pressure from T 2 to T 3 in the control group was smaller compared with that in the observation group. The time to recover consciousness in the observation group was significantly shorter than that in the control group [observation group: (8.76 ± 0.59) minutes, control group: (9.4 ± 0.64) minutes, t = -4.07, P < 0.05]. The incidence of injection pain in the observation group was significantly lower than that in the control group [observation group: 0, control group: 30.00% (9/30), χ2 = 8.36, P < 0.05]. There were no statistically significant differences in time to recover spontaneous breathing, the number (percentage) of patients experiencing headaches, hypotension, increased secretions, or postoperative nausea and vomiting, or the number (percentage) of patients using vasoactive drugs between the two groups (all P > 0.05). Conclusion:When used in modified electroconvulsive therapy, ciprofol can provide excellent anesthetic effects. It results in more stable hemodynamics in patients, causes milder injection pain, and leads to a faster recovery compared with propofol.
