Efficacy of magnesium sulfate plus aspirin in the treatment of pregnancy-induced hypertension and its effect on placental hypoxia-induced factor-1 α levels
10.3760/cma.j.cn341190-20231025-00335
- VernacularTitle:硫酸镁联合阿司匹林治疗妊娠期高血压效果观察及其对胎盘HIF-1α的影响
- Author:
Yun CHEN
1
;
Qing SHEN
;
Jianfen TANG
Author Information
1. 嘉兴市妇幼保健院产科，嘉兴 314000
- Keywords:
Hypertension,pregnancy-induced;
Drug therapy,combination;
Magnesium sulfate;
Aspirin;
Blood pressure;
Hypoxia-inducible factor 1,alpha subunit;
Pregnancy ou
- From:
Chinese Journal of Primary Medicine and Pharmacy
2024;31(7):1043-1047
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the efficacy of magnesium sulfate plus aspirin in the treatment of pregnancy-induced hypertension and its effect on placental hypoxia-induced factor-1α (HIF-1α) levels.Methods:This is a case-control study. The clinical data were collected from 96 patients with gestational hypertension who were admitted to Jiaxing Maternity and Child Health Care Hospital between January 2019 and January 2023. These patients were divided into a control group and a study group, with 48 patients in each group, according to different treatment methods. The control group received magnesium sulfate treatment, whereas the study group was treated with magnesium sulfate combined with aspirin. Both groups were treated for 14 days. The clinical efficacy of the two groups was compared. Pre- and post-treatment blood pressure, placental HIF-1α levels, and endothelin levels were compared between the two groups. The incidence of adverse reactions and adverse pregnancy outcomes were also compared between the two groups.Results:The response rate in the study group was significantly higher compared with that in the control group, with 93.8% (45/48) versus 79.2% (38/48), respectively ( χ2 = 4.36, P < 0.05). Following treatment, both diastolic and systolic blood pressure levels in the study group were significantly lower than those in the control group ( t = 5.70, 7.33, both P < 0.05). Placental HIF-1α and endothelin levels in the study group were (41.03 ± 6.95) μg/L and (93.37 ± 8.29) ng/L, respectively, which were significantly lower than those in the control group [(82.97 ± 8.86) μg/L, (124.96 ± 9.32) ng/L, t = 17.55, 25.80, both P < 0.001]. The incidences of adverse reactions and unfavorable pregnancy outcomes in the study group were 12.5% (6/48) and 10.4% (5/48), respectively. These were significantly lower compared with those in the control group, which were 31.3% (15/48) and 27.1% (13/48), respectively ( χ2 = 4.94, 4.38, both P < 0.05). Conclusion:Magnesium sulfate combined with aspirin is highly effective in treating pregnancy-induced hypertension. This combined therapy can effectively lower patients' diastolic and systolic blood pressures, as well as placental HIF-1α and endothelin levels. It can obviously reduce the incidences of adverse reactions and unfavorable pregnancy outcomes.
