Research progress in the pathogenesis of bortezomib-induced peripheral neuropathy
10.3760/cma.j.cn341190-20230811-00082
- VernacularTitle:硼替佐米诱发周围神经病变发病机制的研究进展
- Author:
Jiao ZOU
1
;
Mimi HUANG
;
Lixia SONG
;
Changqing TONG
Author Information
1. 河北北方学院研究生院，张家口 075000
- Keywords:
Bortezomib;
Peripheral nerves;
Multiple myeloma;
Neurons;
Astrocytes;
Review
- From:
Chinese Journal of Primary Medicine and Pharmacy
2024;31(6):948-952
- CountryChina
- Language:Chinese
-
Abstract:
Bortezomib exerts its anti-myeloma effect by reversibly inhibiting the proteasome through various mechanisms, and it is currently the first-line drug for the treatment of multiple myeloma in China. Bortezomib-induced peripheral neuropathy is one of the most common dose-limiting adverse reactions in the treatment process, which seriously affects the quality of life of patients, leading to dose reduction or even drug withdrawal. How to reduce or prevent Bortezomib-induced peripheral neuropathy remains a challenging problem in the treatment of multiple myeloma. Based on this, this article reviews the pathogenesis of Bortezomib-induced peripheral neuropathy from the perspectives of Schwann cells, neurons, astrocytes, macrophages, and other aspects.
