Progress on application of hydrogels in the field of peripheral nerve injury repair
10.12200/j.issn.1003-0034.20230883
- VernacularTitle:水凝胶在周围神经损伤修复领域的应用研究进展
- Author:
Chun QIN
1
;
Ling-Tong KONG
;
Shuo-Gui XU
Author Information
1. 海军军医大学研究生院,上海 200433
- Keywords:
Hydrogel;
Peripheral nerve injury;
Artificial nerve conduit
- From:
China Journal of Orthopaedics and Traumatology
2024;37(6):629-634
- CountryChina
- Language:Chinese
-
Abstract:
As one of the common traumatic diseases in clinical practice,peripheral nerve injury(PIN)often causes nerve pain,abnormal reflexes,autonomic disorders,and even sensorimotor disorders due to the slow regeneration rate after injury,which seriously affects body function.Even as the gold standard of treatment,autologous nerve transplantation has limitations such as limited donor area and donor injury,which greatly limits its clinical application effect.Therefore,the preparation of ar-tificial nerve grafts suitable for clinical practice has become the future development trend of peripheral nerve injury treatment,and the repair of injury defects and the promotion of nerve regeneration have also become research hotspots in tissue engineer-ing and regenerative medicine.In recent years,extensive research has been carried out on nerve guidance conduits(NGCs)in the field of nerve regeneration and repair,in which scaffold materials and intemal fillers have also become the focus of research as the core elements of neural catheters,and a series of achievements have been made in the application of new materials,em-bedding stem cells/precursor cells,and developing trophic factors and drug-loaded sustained-release systems.Therefore,this paper focuses on the application progress of hydrogel and its related derivative materials in the field of peripheral nerve injury repair,and provides new ideas for promoting the related research of tissue engineering and clinical medicine.
