Effect of distal ischemic preconditioning on cardiovascular events in adult patients with hip fracture one year after operation
10.12200/j.issn.1003-0034.20220781
- VernacularTitle:远端缺血预处理对髋部骨折老年患者术后1年心血管事件的影响
- Author:
Li-Na ZHANG
1
;
Yan-Ge ZHANG
;
Yong-Quan WU
Author Information
1. 濮阳市中医院麻醉科,河南 濮阳 457000
- Keywords:
Distal ischemic preconditioning;
Hip fracture;
Cardiovascular events
- From:
China Journal of Orthopaedics and Traumatology
2024;37(5):487-491
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of remote ischemic preconditioning(RIPC)on major adverse cardiovascu-lar events(MACE)in elderly patients with hip fracture 1 year after operation.Methods Total of 314 elderly patients with hip fracture of grade Ⅱ and Ⅲ for American Society of Anesthesiologists(ASA)were treated by surgical operation from April 2015 to May 2020 including 116 males and 198 females,the age ranged from 60 to 76 years old.The subjects were divided into in-tervention group and control group according to whether received RIPC.Among them,157 cases in intervention group included 56 males and 101 females with an average age of(68.12±7.13)years old and 157 cases in control group included 60 males and 97 females with an average age of(68.24±7.05)years old.Both groups were given routine anesthesia.The intervention group was treated with RIPC on the basis of routine anesthesia.The MACE events 1 year after operation in two groups were com-pared and analyzed.Results The OR values of RIPC for myocardial infarction,heart failure,stroke,nonfatal cardiac arrest,coronary revascularization,severe arrhythmia,peripheral artery thrombosis,readmission of cardiovascular disease,and all-cause death in patients with hip fracture one year after operation were 1.269,1.304,0.977,1.089,1.315,1.335,0.896,0.774,1.191,respectively,but there was no significant difference(P＞0.05).Conclusion RIPC did not significantly affect and change the occurrence of major cardiovascular adverse events within 1 year after hip fracture surgery.The long term impact of RIPC on clinical cardiovascular outcomes in non cardiac surgery needs to be confirmed in appropriate randomized clinical trials.
