Studies on Histological Mechanism of Bone Loss of Castrated Male Rats
10.3969/j.issn.1003-0034.2001.04.007
- VernacularTitle:去睾大鼠骨丢失的组织学机理研究
- Author:
Yi CHENG
1
;
Hang ZHU
;
Hai HUANG
Author Information
1. Hangzhou Chinese Traditional Medicine Hospital
- From:
China Journal of Orthopaedics and Traumatology
2001;14(4):209-211
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the histological mechanism of the bone loss of castrated male rats and provied theoretical basis for clinical treatment.Methods 30 male rats aged 10 months were randomly divided into two groups as normal and castrated pathological groups.The animals were sacrificed after adminsration Heihudan (a TCM agent) for 12 weeks.L1 and L2 were chosen to make bone slices without decalificating and then diverse bone indexes and superficial indexes of bone morphological metrology were determined.ANOVA was used for data anlysis.Results Bone indexes in the pathological group were smaller than the normal one(P<0.05).The superficial indexes show:osteoclast index increased,osteogenesis index decreased,bone transformation became faster than before(P<0.05).Conclusion Reconstruction of negative balance and high bone transformation were the mechanisms of the bone loss of castrated male rats.The method of combining with drugs to promote bone formation,restrain bone absorption,reduce bone transformation seems to be useful for the treatment of senile male patients with osteoporosis.
