Experimental study of the effects of Fuyuansan on microcirculation of steroid-induced necrosis of femoral head in rabbits

VernacularTitle:复元散对激素性股骨头坏死微循环影响的实验研究
Author: Jia-Yuan HONG ¹ ; Shu-Liang XU ; Jing-Chuo RUAN
Author Information

1. The 175th Hospital of PLA
Keywords: Femur head necrosis Drugs; Chinese herbal Microcirculation
From: China Journal of Orthopaedics and Traumatology 2001;14(1):27-28
CountryChina
Language:Chinese
Abstract: Objective　To study the effects of Fuyuansan(Chinese herbal medicine) on microcirculation of steroid-induced necrosis of femoral head.Methods　40 male adult New Zealand rabbits were randomly divided into three groups:model group(n=15),Fuyuansan group(n=15) and control group(n=10).Hydroprednisone acetate was injected into the rabbits of the model group using intragluteal injection to produce necrosis models of bone cells of femoral head.The rabbits of Fuyuansan group were injected the same agent using the same methods as model group.Meanwhile,the animals of Fuyuansan group were given Fuyuansan daily.The whole-blood viscosity,triglyceride,serum total cholesterol and intraosseous pressure of each group were determined every two weeks.Results　The whole-blood viscosity,triglyceride,serum total cholesterol and intraosseous pressure of model group remarkably increased,but those of Fuyuansan group increased lightly(P<0.01).Conclusion　Fuyuansan can improve microcirculation of femoral head,change ischemia conditions and prevent the development of necrosis of femoral head.