Risk factors of central line-associated bloodstream infection in the inten-sive care unit based on propensity score matching
10.12138/j.issn.1671-9638.20246221
- VernacularTitle:基于倾向性评分匹配的ICU中心静脉导管相关血流感染危险因素
- Author:
Zhi-Mei TENG
1
;
Shang ZHU
;
Han XUE
;
Jin-Hua HUANG
;
Xu-Hui KONG
Author Information
1. 泰州市人民医院医院感染管理处,江苏 泰州 225300
- Keywords:
central line-associated bloodstream infection;
central venous catheter;
propensity score matching;
risk factor;
CLABSI
- From:
Chinese Journal of Infection Control
2024;23(11):1405-1412
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the independent risk factors for central line-associated bloodstream infection(CLABSI),provide basis for developing intervention measures for infection prevention and control as well as con-ducting targeted treatment.Methods Patients who were diagnosed with CLABSI in a hospital from January 2019 to December 2023 were recruited retrospectively and defined as the infection group.According to 1:4 propensity score matching method,patients who received central venous catheter(CVC)without infection were taken as the control group.With whether CLABSI occurred as the dependent variable,the possible risk factors of the matched two groups as the independent variables,logistic regression analysis was conducted,and independent risk factors for pa-tients developing CLABSI were explored.Results A total of 42 patients in the CLABSI group and 168 patients in the non-CLABSI group were matched.Multivariate logistic regression analysis showed that high score of acute physiology and chronic health evaluation(APACHE)Ⅱ(OR=1.217,95％CI[1.094-1.357],P＜0.001),long duration of central venous catheterization(OR=1.273,95％CI[1.157-1.400],P＜0.001),and femoral venous catheterization(OR=6.846,95％CI[1.511-31.014],P=0.013)were independent risk factors for CLABSI.A total of 118 strains of pathogens were isolated from 42 CLABSI patients,with Gram-negative bacteria being the ma-jority(n=56).Conclusion High score of APACHE Ⅱ,long duration of central venous catheterization,and femo-ral venous catheterization are independent risk factors for CLABSI.The main pathogens are Gram-negative bacilli.Strict prevention and control measures for CLABSI should be implemented to reduce the risk of infection.
