Application of combined detection of Mycobacterium tuberculosis-specific IFN-γ and IL-2 in the differential diagnosis of pulmonary tuberculosis and bacterial pneumonia
10.12138/j.issn.1671-9638.20246085
- VernacularTitle:结核分枝杆菌特异性IFN-γ、IL-2联合检测在肺结核与细菌性肺炎鉴别诊断中的应用
- Author:
Jing XU
1
;
Wei WANG
;
Tuan-Tuan LI
Author Information
1. 阜阳市人民医院检验科,安徽阜阳 236000
- Keywords:
pulmonary tuberculosis;
bacterial pneumonia;
IFN-γ;
IL-2;
combined detection;
differential diagnosis
- From:
Chinese Journal of Infection Control
2024;23(9):1173-1177
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the application value of combined detection of Mycobacterium tuberculosis-spe-cific cytokines interferon-γ(IFN-γ)and interleukin-2(IL-2)in the differential diagnosis of pulmonary tuberculosis and bacterial pneumonia.Methods A total of 91 hospitalized patients in the respiratory department of Fuyang Peo-ple's Hospital from January 2022 to October 2023 were selected.Forty-five patients were diagnosed with pulmonary tuberculosis(pulmonary tuberculosis group),and 46 patients were diagnosed with bacterial pneumonia(pneumonia group).Two-cytokine combined detection were performed on all patients.The effect of two-cytokine combined de-tection and C-reactive protein(CRP)in the differential diagnosis of pulmonary tuberculosis and bacterial pneumonia was compared.Results The sensitivity and specificity of two-cytokine combined detection for the differential diag-nosis of pulmonary tuberculosis and bacterial pneumonia were 86.7％and 84.8％,respectively.The area under the receiver operating characteristic curve was 0.928(95％CI:0.870-0.986),which showed significant difference compared with differential diagnostic efficacy of CRP(P＜0.05).Conclusion The combined detection of Mycobac-terium tuberculosis-specific cytokine IFN-γ and IL-2 in the differential diagnosis of pulmonary tuberculosis and bacte-rial pneumonia has a high application value,which can provide a basis for the differential diagnosis of pulmonary tuber-culosis and bacterial pneumonia.
