Diagnosis,treatment,prevention and control of bloodstream infection caused by non-O1/non-O139 Vibrio cholerae:two cases report
10.12138/j.issn.1671-9638.20244506
- VernacularTitle:非O1群非O139群霍乱弧菌血流感染的诊疗及防控2例报告
- Author:
Tian-Chi MA
1
;
Lu BAI
;
Rou-Gang XIE
;
Ke ZHOU
;
Fei SUN
;
Ke-Yong TIAN
Author Information
1. 空军军医大学基础医学院学员六大队二十二队,陕西 西安 710032
- Keywords:
non-O1/non-O139 Vibrio cholerae;
bloodstream infection;
serological typing;
antimicrobial suscepti-bility;
infection prevention and control
- From:
Chinese Journal of Infection Control
2024;23(6):687-691
- CountryChina
- Language:Chinese
-
Abstract:
Objective To identify and conduct antimicrobial susceptibility testing on Vibrio species isolated from blood culture specimens of two patients with bloodstream infection(BSI),analyze the microbiological characteristics of non-O1/non-O139 Vibrio cholerae(NOVC),and provide evidence for the diagnosis,prevention and control of Vibrio cholerae infection.Methods Two Vibrio strains were identified by matrix-assisted laser desorption/ioniza-tion time-of-flight mass spectrometry(MALDI-TOF MS),API bacterial biochemical reaction identification test strip,VITEK 2 Compact identification instrument and 16S rRNA gene sequencing.Serological typing,virulence gene molecular detection,and drug resistance phenotype detection were performed to the Vibrio strains.Results Two strains were identified as Vibrio cholerae,classified as NOVC by serological typing,and were negative for ctxAB virulence gene detection.Antimicrobial susceptibility testing showed that one strain was sensitive to ampici-llin,azi-thromycin,doxycycline and chloramphenicol,while resistant to tetracycline and trimethoprim-sulfametho-xazole.The other strain was sensitive to all tested antimicrobial agents.Conclusion BSI caused by NOVC is rarely reported in China.Accurate identification,typing and drug-resistant phenotype detection of Vibrio cholerae isolated from blood culture specimens are valuable for the diagnosis,treatment,prevention and control of Vibrio cholerae-associated infection.
