Testing of tuberculosis infection among Chinese adolescents born after terminating the Bacillus Calmette-Guérin booster vaccination: subgroup analysis of a population-based cross-sectional study
- Author:
Li HENGJING
1
;
Xin HENAN
;
Qian SHUKUN
;
Li XIANGWEI
;
Zhang HAORAN
;
Li MUFEI
;
Feng BOXUAN
;
Jin QI
;
Gao LEI
Author Information
1. MOH Key Laboratory of Systems Biology of Pathogens
- Keywords:
tuberculin skin test;
interferon-γ release assays;
adolescent;
agreement
- From:
Frontiers of Medicine
2017;11(4):528-535
- CountryChina
- Language:Chinese
-
Abstract:
The prevalence of tuberculosis infection among adolescents born after terminating the Bacillus Calmette-Guérin (BCG) booster vaccination in China was estimated using tuberculin skin testing (TST) and QuantiFERON-TB Gold assay (QFT) to investigate the influence of neonatal BCG vaccination on the performance of TST.Data analysis was conducted for 2831 eligible participants aged 5-15 years from the baseline survey of a population-based multi-center prospective study.The prevalence rates of TST (induration ≥ 10 mm) and QFT positivity were 9.3％ (264/2827) and 2.5％ (71/2831),respectively.The rate of QFT indeterminate result was 2.2％ (62/2831).The overall agreement between TST and QFT was low (concordance =88.0％;K coefficient =0.125).Only TST was positively associated with BCG vaccination with an adjusted odds ratio of 1.71 [95％ confidence interval,1.26-2.31].A history of close contact with patients of active TB was significantly associated with positivity for TST and QFT.Our results suggested that BCG neonatal vaccination still affects TST performance,and a two-step approach might be considered for TB infection testing among adolescents in China.
