Philadelphia chromosome-positive acute myeloid leukemia with masses and osteolytic lesions: finding of 18F-FDG PET/CT
10.1007/s11684-017-0523-x
- Author:
Su ZHAN
1
;
Wu FENGYU
;
Hu WEIYU
;
Liu XIAODAN
;
Wu SHAOLING
;
Feng XIANQI
;
Cui ZHONGGUANG
;
Yang JIE
;
Wang ZHENGUANG
;
Guan HONGZAI
;
Zhao HONGGUO
;
Wang WEI
;
Zhao CHUNTING
;
Peng JUN
Author Information
1. Department of Haematology
- Keywords:
Philadelphia chromosome;
acute myeloid leukemia;
mass;
osteolysis;
positron emission tomography
- From:
Frontiers of Medicine
2017;11(3):440-444
- CountryChina
- Language:Chinese
-
Abstract:
Philadelphia chromosome-positive acute myeloid leukemia is controversial and difficult to distinguish from the blast phase of chronic myeloid leukemia.As a myeloid neoplasm,rare cases of this leukemia manifest multiple soft-tissue tumors or bone lytic lesions.In this paper,we describe a 49-year-old male patient who had an abrupt onset with sharp chest pain,fever,fatigue,emaciation,and splenomegaly.18F-fluoro-deoxy-glucose positron emission tomography/computed tomography (18F-FDG PET/CT) result showed diffuse and uneven hypermetabolic lesions in the bone marrow with peripheral bone marrow expansion,multiple soft tissue neoplasms with high 18F-FDG uptake,and lytic bone lesions.Bone marrow smear and biopsy detected aberrant blast cells expressing myeloid rather than lymphoid immunophenotype marker.For the existence of Philadelphia chromosome and BCR-ABL1 fusion gene together with complex chromosome abnormalities,a diagnosis of Philadelphia-positive acute myeloid leukemia was made,although the type (de novo or blast crisis) remained unclear.
