Arsenic trioxide induced rhabdomyolysis, a rare but severe side effect, in an APL patient: a case report
10.1007/s11684-017-0514-y
- Author:
He HAIYAN
1
;
An RAN
;
Hou JIAN
;
Fu WEIJUN
Author Information
1. Myeloma and Lymphoma Center
- Keywords:
arsenic trioxide;
APL;
rhabdomyolysis
- From:
Frontiers of Medicine
2017;11(2):284-286
- CountryChina
- Language:Chinese
-
Abstract:
Arsenic trioxide (ATO),a component of the traditional Chinese medicine arsenic sublimate,promotes apoptosis and induces leukemic cell differentiation.Combined with all-trans-retinotic acid (ATRA),ATO has become the first-line induction therapy in treating acute promyelocytic leukemia (APL).The most common side effects of ATO include hepatotoxicity,gastrointestinal symptoms,water-sodium retention,and nervous system damage.In this report,we present a rare side effect,rhabdomyolysis,in a 68-year-old female APL patient who was treated with ATO.After taking 10 mg ATO daily for 6 days,she presented shortness of breath,myodynia,elevated creatine kinase,and acute renal insufficiency.This report describes the first case of ATO-induced rhabdomyolysis.
