Calculation method of paternity index in parentage testing of both paternal and maternal mutations
10.13618/j.issn.1001-5728.2024.04.001
- VernacularTitle:父系母系均突变的双亲鉴定亲权指数计算方法
- Author:
Shichao WU
1
;
Mi ZHOU
Author Information
1. 安徽警官职业学院,安徽合肥 230031
- Keywords:
Forensic genetics;
Autosomal STR;
Paternity index;
Mutation
- From:
Chinese Journal of Forensic Medicine
2024;39(4):395-398
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore a method of calculating the paternity index(PI)in parentage testing of both paternal and maternal mutations.Methods In this study,the general formulas of PI in parentage testing were derived based on Mendel's laws of inheritance and mutation basic model first.Subsequently,on the basis of the general formula,parentage testing of both paternal and maternal mutations were classified into 8 types according to child-mother-father genotypes.From,these classifications,detailed formulas of PI in alleged father cases(PIAF)and PI in alleged parent cases(PIAP)were further refined.Finally,a simulation experiment was designed to generate 10,000 parents composed of unrelated individuals on 19 autosomal loci of the EX20 kit,and the percentages of mutations of confirming group(c group),single mutant group(s group),and double mutants group(d group)were calculated.the min,max,and arithmetic mean(x)of PI in alleged father groups and alleged parent groups were all calculated based on simulated data.Meanwhile,the min,max,and geometric mean(Π)of cumulative parentageindex(CPI)were calculated in the same two groups.Results In this study,All PI formulas of both paternal and maternal mutations in parentage testing were derived.The conclusive analysis of the min,max and mean(x)of PI in group c,group s,and group d led out the following rules:minc>mins>mind,maxc>maxs>maxd,xc>xs>xd.The CPI of all simulation cases met the conditions of excluding kinship.Conclusion The PI formulas in this paper could be applied to parentage testing of both paternal and maternal mutations.
