Research progress of PRDX6 in cardiovascular diseases
10.20039/j.cnki.1007-3949.2024.11.002
- VernacularTitle:PRDX6在心血管疾病中的研究进展
- Author:
Rumei XIE
1
,
2
;
Jiakang LI
;
Mengge YAO
;
Li ZHANG
Author Information
1. 福建医科大学心血管疾病离子通道与信号转导省高校重点实验室,福建省 福州市 350102
2. 福建医科大学附属协和医院心外科,福建省 福州市 350001
- Keywords:
Peroxiredoxin 6;
cardiovascular disease;
oxidative stress;
inflammation
- From:
Chinese Journal of Arteriosclerosis
2024;32(11):932-938
- CountryChina
- Language:Chinese
-
Abstract:
In the study of cardiovascular diseases,Peroxiredoxin 6(PRDX6)is the only mammalian 1-Cys member of the Peroxiredoxin(PRDX)family and has attracted much attention.PRDX6 plays a unique role in oxidative stress due to its peroxidase activity and phospholipase A2 activity,and has been shown to participate in redox homeostasis and phos-pholipid metabolism.In recent years,the role of PRDX6 in the occurrence and development of cardiovascular diseases has received great attention.However,there is no unified understanding of the function of PRDX6 in the cardiovascular system at present.This article aims to briefly summarize the research progress of PRDX6 in cardiovascular diseases such as atherosclerosis,pulmonary hypertension,myocardial infarction,heart failure,abdominal aortic aneurysm,and systemat-ically review the expression changes,mechanism of action,and possible therapeutic potential of PRDX6 in these cardiovas-cular diseases,hoping to provide new ideas and strategies for cardiovascular diseases intervention.
