Role of inflammatory factors in the development of in-stent restenosis
10.20039/j.cnki.1007-3949.2024.09.010
- VernacularTitle:炎症因子在支架内再狭窄发生发展中的作用
- Author:
Ming YU
1
;
Yuxing WANG
;
Song YANG
;
Nan NIU
;
Peng QU
Author Information
1. 大连医科大学附属第二医院,辽宁省大连市 116021
- Keywords:
in-stent restenosis;
inflammatory factors;
intimal hyperplasia;
in-stent neoatherosclerosis
- From:
Chinese Journal of Arteriosclerosis
2024;32(9):805-812
- CountryChina
- Language:Chinese
-
Abstract:
In-stent restenosis(ISR)is a significant cause of long-term prognosis after percutaneous coronary inter-vention(PCI).The inflammatory response is a critical factor in its development.Unlike the chronic inflammatory process of traditional atherosclerosis,ISR may develop acute coronary events within even months or years,and the inflamma-tory mechanisms of ISR are more complex.Inflammatory factors regulate various mechanisms,including monocyte macro-phage proliferation,endothelial cell damage and repair,foam cell formation,and smooth muscle cell proliferation and migra-tion after PCI.The review briefly describes the classification and risk factors of ISR.It emphasizes the role of various in-flammatory factors in ISR to provide new ideas for investigating the inflammatory mechanism of ISR and clinical intervention.
