Analysis of influencing factors of major adverse cardiovascular events after drug-eluting stent implantation in young and middle-aged patients with coronary artery disease
10.20039/j.cnki.1007-3949.2024.09.005
- VernacularTitle:中青年冠状动脉疾病患者药物洗脱支架植入术后主要不良心血管事件发生的影响因素分析
- Author:
Chunjing GU
1
;
Changguo ZHU
;
Zhaoyun MENG
Author Information
1. 济南市人民医院全科医学科,山东省济南市 271100
- Keywords:
coronary artery disease;
drug-eluting stent;
major adverse cardiovascular events
- From:
Chinese Journal of Arteriosclerosis
2024;32(9):771-776
- CountryChina
- Language:Chinese
-
Abstract:
Aim To explore the influencing factors of major adverse cardiovascular events(MACE)after drug-e-luting stent(DES)implantation in young and middle-aged patients with coronary artery disease(CAD).Methods Retrospective study data from the First Affiliated Hospital of Zhengzhou University were extracted from the Dryad database,and young and middle-aged CAD patients who received DES were divided into MACE group(n=57)and non MACE group(n=321)according to whether MACE occurred during the follow-up period.Clinical data including age,gender etc.were compared between the two groups,and the variables with significant differences between the two groups were substitu-ted into Logistic regression model to screen the influencing factors of MACE after DES implantation in young and middle-aged CAD patients.Value of influencing factors predicting occurrence of MACE after DES implantation in young and mid-dle-aged CAD patients was evaluated by plotting ROC curve and calculating the area under the curve(AUC).Results Stent diameter in MACE group was significantly smaller than that in non MACE group(P＜0.001),the number of left main coronary artery lesion in MACE group was significantly higher than that in non MACE group(P＜0.05).Multivariate Lo-gistic regression analysis indicated that stent diameter(OR=0.184,95％CI:0.084～0.405,P＜0.001)and left main coronary artery lesion(OR=9.319,95％CI:2.291～37.904,P=0.002)were the independent risk factors of MACE after DES implantation in young and middle-aged CAD patients.The risk of MACE after DES implantation in young and middle-aged CAD patients significantly decreased when the stent diameter was＞3 mm.The AUC of stent diameter com-bined with left main coronary artery lesion predicting occurrence of MACE after DES implantation in young and middle-aged CAD patients was 0.700(95％CI:0.623～0.776).Conclusion The smaller stent diameter and left main coronary artery lesion are the influencing factors of the occurrence of MACE after DES implantation in young and middle-aged pa-tients with CAD,and should be emphasized by clinical practitioners.
