Research progress on the role and mechanism of copper overload mediating athero-sclerosis
10.20039/j.cnki.1007-3949.2024.08.011
- VernacularTitle:铜过载介导动脉粥样硬化的作用及机制研究进展
- Author:
Tian WANG
1
;
Hongfei WU
;
Min DAI
;
Yarong LIU
Author Information
1. 安徽中医药大学药学院,安徽省合肥市 230011
- Keywords:
atherosclerosis;
copper homeostasis;
copper overload;
cuproptosis
- From:
Chinese Journal of Arteriosclerosis
2024;32(8):719-727
- CountryChina
- Language:Chinese
-
Abstract:
Atherosclerosis(As)is a chronic inflammatory disease associated with lipid deposition.Copper is con-sidered to be an important trace element and is closely related to the occurrence and development of As.Excessive accu-mulation of copper ions in cells can induce cell death,a new type of cell death named"cuproptosis".Under normal con-ditions,the body's copper metabolism can control the copper level in a stable range.When the disease occurs,copper ho-meostasis is destroyed,intracellular copper overload produces cytotoxicity,induces oxidative stress,inflammation,cell py-roptosis and cuproptosis,and promotes the occurrence and development of As.This article summarizes the relationship between copper levels and As,and discusses the mechanism of cuproptosis and the pathological mechanism of copper over-load promoting As from the perspective of the body's copper regulation,and reviews the relevant drug intervention,expec-ting to provide a new therapeutic target for As.
