Research progress of TLR4 in acute myocardial infarction and its treatment

VernacularTitle:TLR4参与急性心肌梗死及其治疗的研究进展
Author: Chuting HU ^{1
,

2} ; Yu SONG ; Lin WANG
Author Information

1. 华中科技大学同济医学院附属协和医院检验科,湖北省武汉市 430022
2. 华中科技大学同济医学院附属协和医院组织工程与再生医学研究中心,湖北省武汉市 430022
Keywords: acute myocardial infarction; Toll-like receptor 4; inflammation
From: Chinese Journal of Arteriosclerosis 2024;32(8):705-711
CountryChina
Language:Chinese
Abstract: Acute myocardial infarction(AMI)is a severe disease caused by the persistent coronary artery obstruc-tion,posing a great threat to people's health.In recent years,Toll-like receptor4(TLR4),an important pattern recogni-tion receptor,has been widely studied and found to play a crucial role in AMI.This review introduces the recent progress of TLR4 in regulating the progression and prognosis of AMI,and summarizes recent TLR4-targeted therapies using clinical drugs,TLR4 inhibitors,mesenchymal stem cells,and natural bioactive molecules,providing valuable insights for address-ing myocardial damage caused by AMI and improving prognosis.