Predictive value of residual lipoprotein cholesterol in the occurrence and severity of peripheral arterial disease in patients with type 2 diabetes mellitus
10.20039/j.cnki.1007-3949.2024.08.006
- VernacularTitle:血浆残粒脂蛋白胆固醇水平对2型糖尿病患者外周动脉疾病发生及严重程度的相关性分析
- Author:
Jinrui JI
1
;
Bin XUE
;
Wenshan CHEN
;
Lei WU
;
Dongyu WAN
;
Hengliang LIU
Author Information
1. 河南中医药大学第五临床医学院 河南中医药大学人民医院,河南省郑州市 450000
- Keywords:
residual lipoprotein cholesterol;
type 2 diabetes mellitus;
peripheral arterial disease;
predictive value
- From:
Chinese Journal of Arteriosclerosis
2024;32(8):683-689
- CountryChina
- Language:Chinese
-
Abstract:
Aim To explore the correlation between residual lipoprotein cholesterol(RLP-C)and the occurrence and severity of peripheral arterial disease(PAD)in patients with type 2 diabetes mellitus(T2DM).Meth-ods 392 T2DM patients with complete data who attended the Department of Endocrinology and the Department of Cardio-vascular Medicine of People's Hospital of Henan University of Traditional Chinese Medicine from May 2022 to December 2022 were selected and classified into PAD group(n=203)and non-PAD group(n=189).General clinical data were collected between the groups,the difference of RLP-C level was compared between the two groups,the correlation between RLP-C and PAD was examined by using univariate and multivariate Logistic regression analysis,and ROC curve was plotted to analyze the predictive value of RLP-C for PAD.Results Compared with non-PAD group,RLP-C level was significantly higher in PAD group(P＜0.001);RLP-C was positively correlated with the severity of PAD(r=0.443,P＜0.001);Multifactorial Logistic regression analysis revealed that RLP-C was a major risk factor for the development of PAD in T2DM(P＜0.001);The area under the curve(AUC)of RLP-C level prediction for T2DM combined with PAD was 0.860(95％CI:0.824～0.896,P＜0.001);The optimal RLP-C threshold for predicting the development of PAD was 0.67 mmol/L.Conclusion RLP-C level was positively associated with the occurrence and severity of PAD in patients with T2DM,and RLP-C was an independent risk factor for the development of PAD.In addition,RLP-C＞0.67 mmol/L increased the risk of PAD in T2DM patients.
