The role and mechanism of N6-methyladenosine modification in atherosclerosis
10.20039/j.cnki.1007-3949.2024.07.012
- VernacularTitle:m6A修饰在动脉粥样硬化中的作用及其机制
- Author:
Tingting JIA
1
;
Guofu ZHU
Author Information
1. 昆明医科大学第二附属医院心血管内科,云南省昆明市 650000
- Keywords:
atherosclerosis;
m6A modification;
vascular endothelial cell;
vascular smooth muscle cell;
macrophage;
lipid metabolism
- From:
Chinese Journal of Arteriosclerosis
2024;32(7):634-640
- CountryChina
- Language:Chinese
-
Abstract:
Atherosclerosis(As)is the pathological basis of various vascular diseases,which affects the function of important organs.Recent studies have found that N6-methyladenosine(m6A)modification plays a vital role in As.This paper summarizes the regulatory effects of m6A modification on vascular endothelial cell(VEC)injury,vascular smooth muscle cell(VSMC)transformation,macrophage(M?)differentiation,foam cell(FC)formation,pyroptosis,and lipid regulation,and summarizes the regulation function of some m6 A regulatory proteins in As.
