Research progress in the role of m6A methylation in the pathogenesis of myocardial remodeling after myocardial infarction
10.20039/j.cnki.1007-3949.2024.07.009
- VernacularTitle:m6A甲基化在心肌梗死后心肌重构发病机制中的研究进展
- Author:
Changxu XIE
1
,
2
;
Shuaijie GUO
;
Siqi CHEN
;
Lei ZHANG
;
Weihong LIU
;
Sinai LI
;
Mingxue ZHOU
Author Information
1. 首都医科大学附属北京中医医院
2. 北京市中医药研究所,北京市 100010
- Keywords:
m6A methylation;
myocardial infarction;
myocardial remodeling;
heart failure
- From:
Chinese Journal of Arteriosclerosis
2024;32(7):613-620
- CountryChina
- Language:Chinese
-
Abstract:
Myocardial infarction is the most common cause of heart failure,and myocardial remodeling can occur after infarction,thus contributing to the progression of heart failure.The occurrence of post-infarction ventricular remode-ling is closely related to m6A methylation.m6A methylation is a reversible and highly dynamic process.This process is mainly mediated by m6A methylation positive and negative regulatory enzymes and is involved in the occurrence of post-in-farction myocardial remodeling through mechanisms such as cellular autophagy.This article mainly reviews relevant litera-ture in recent years.Firstly,a brief introduction is given to m6A methylation,followed by an introduction to the role of m6A methylase in regulating myocardial remodeling.Finally,a summary analysis is conducted on the mechanism of m6A methylation in regulating myocardial remodeling from the perspectives of autophagy,inflammation,cell apoptosis,calcium ion homeostasis,extracellular matrix remodeling,and ferroptosis.The feasibility of using m6A methylation serological de-tection as a diagnostic tool for myocardial remodeling after myocardial infarction is discussed,in order to provide reference for related research.
