Application of biomaterials in cardiac regeneration and repair
10.20039/j.cnki.1007-3949.2024.06.012
- VernacularTitle:生物材料在心脏再生修复过程中的应用
- Author:
Xueping WU
1
,
2
;
Yehui LÜ
Author Information
1. 上海健康医学院人体解剖与组织胚胎学教研室,上海市 201318
2. 上海健康医学院创面防治研究所,上海市 201318
- Keywords:
ischemic heart disease;
acellular biomaterials;
cardiac surgery;
cardiac regeneration;
angio-genesis
- From:
Chinese Journal of Arteriosclerosis
2024;32(6):539-546
- CountryChina
- Language:Chinese
-
Abstract:
Myocardial infarction is myocardial necrosis caused by acute and persistent ischemia and hypoxia of coro-nary artery,with high incidence rate and mortality.Although the recovery of blood supply through coronary intervention or thrombolytic drugs can improve the survival rate of patients,it is difficult to rescue the lost cardiomyocytes in the infarcted area,and the limited self repair ability of the adult mammalian heart is the main factor that causes myocardial fibrosis and eventually progresses to heart failure.For a long time,the existing treatment methods are difficult to reverse the process of heart failure after myocardial infarction.Cell transplantation is a promising therapeutic method to promote the repair and regeneration of infarcts.Due to the ischemia and hypoxia microenvironment,the limited survival and retention of stem cells after transplantation are not ideal.And acellular biomaterials promoting angiogenesis and reducing fibrosis show the potential of preclinical treatment.This paper summarizes the advantages and disadvantages of various acellular biomateri-als,epicardial infarct repair and intramyocardial injection in a minimally invasive manner to promote cardiac regeneration and improve cardiac function,and to promote myocardial regeneration by combining acellular biomaterials with optimized drugs in the future for reference.
