The role of dipeptidyl peptidase 4 and its physiological substrate in myocardial ische-mia/reperfusion injury

VernacularTitle:二肽基肽酶4及其生理底物在心肌缺血再灌注损伤中的作用
Author: Lingwei WANG ^{1
,

2} ; Jianghui LEI ; Yadi ZHU ; Siyuan YANG ; Xingkai QIAN
Author Information

1. 贵州医科大学转化医学研究中心,贵州省贵阳市 550025
2. 贵州医科大学药学院,贵州省贵阳市 550025
Keywords: myocardial ischemia/reperfusion injury; dipeptidyl peptidase 4; endogenous peptides
From: Chinese Journal of Arteriosclerosis 2024;32(6):532-538
CountryChina
Language:Chinese
Abstract: Myocardial ischemia/reperfusion injury(MIRI)occurs after cardiopulmonary bypass open heart surgery,cardiovascular intervention and thrombolytic therapy,which is the most important cause of cardiac insufficiency,heart fail-ure,and even death in patients after treatment.In recent years,studies have found that the release of endogenous active peptides can alleviate the production of MIRI,and regulating the function and action of endogenous peptides may be one of the most effective ways to treat MIRI.Dipeptidyl peptidase 4(DPP4)is an important serine protease in mammals,with enzymatic activity to hydrolyze endogenous peptides.Its primary physiological function is to metabolize short peptides,in-cluding growth factors,hormones,etc.This review aims to better understand and search for effective therapeutic targets by elucidating the impact of DPP4 on the hydrolysis of endogenous peptides in MIRI,and ultimately provide new ideas for the therapeutic effects of MIRI.