Research progress on abnormal mitochondrial morphology in human diseases
10.20039/j.cnki.1007-3949.2024.06.005
- VernacularTitle:人类疾病中线粒体异常形态的研究进展
- Author:
Yi LI
1
;
Danling WANG
Author Information
1. 南华大学衡阳医学院,湖南省衡阳市 421001
- Keywords:
human diseases;
mitochondria;
abnormal morphology
- From:
Chinese Journal of Arteriosclerosis
2024;32(6):487-493
- CountryChina
- Language:Chinese
-
Abstract:
Mitochondria are the"power generators"in eukaryotic cells,therefore playing vital roles for basically all cellular activities.Not only supplying energy,mitochondria are also actively regulating important cellular processes,such as apoptosis,differentiation,and proliferation.But mitochondria are not"perpetual motion machines".In fact,mito-chondria are one of the most sensitive organelles to various pathological conditions.Dysfunction of mitochondria can cause many human diseases,such as Alzheimer's disease,diabetes,ischemic heart disease,etc.It is well known that changes in mitochondrial morphology affect the mitochondrial function,and vice versa.Under pathological conditions,mitochondria undergo various morphological changes.Research studies that characterized abnormal mitochondrial mor-phology have enabled us to understand the mitochondrial involvement in the pathogenesis of certain human diseases.This review mainly summarizes the research progress on mitochondrial morphological changes in human diseases,aiming to pro-vide a theoretical overview.
