Mitochondria-associated organelle crosstalk in myocardial ischemia/reperfusion injury
10.20039/j.cnki.1007-3949.2024.06.004
- VernacularTitle:心肌缺血再灌注损伤中的线粒体相关细胞器串扰
- Author:
Hui YAO
1
;
Yuxin XIE
;
Chaoquan LI
;
Wanting LIU
;
Yaqian LUO
;
Guanghui YI
Author Information
1. 南华大学心血管疾病研究所动脉硬化学湖南省重点实验室湖南省动脉硬化性疾病国际科技创新合作基地
- Keywords:
mitochondria;
organelle crosstalk;
myocardial ischemia/reperfusion injury;
mitochondria-associ-ated endoplasmic reticulum membrane;
lysosomes;
cell nucleus
- From:
Chinese Journal of Arteriosclerosis
2024;32(6):481-486
- CountryChina
- Language:Chinese
-
Abstract:
Damage to organelles plays a significant role in myocardial ischemia/reperfusion injury,which results in the dysfunction of mitochondria and other related organelles.The communication between mitochondria and other organ-elles can also affect the development of myocardial ischemia/reperfusion injury.For instance,the mitochondria-associated endoplasmic reticulum membrane provides a"seamless connection"and regulates the exchange of organelles and metabolites(such as ions,lipids and proteins)between the mitochondria and the endoplasmic reticulum,which subse-quently affects myocardial ischemia/reperfusion injury.However,there is a lack of studies regarding the interaction be-tween mitochondria and related organelles,which is a critical component in triggering myocardial ischemia/reperfusion inju-ry.Therefore,this article describes the role of mitochondrial crosstalk with endoplasmic reticulum,lysosomes and nuclei in myocardial ischemia/reperfusion injury,and aims to provide a theoretical basis for targeting mitochondrial crosstalk with other organelles in the treatment of myocardial ischemia/reperfusion injury.
