The role of innate immunity in calcific aortic valve disease

VernacularTitle:先天性免疫在钙化性主动脉瓣疾病中的作用
Author: Xiangjie LIN ¹ ; Qingchun ZENG
Author Information

1. 南方医科大学南方医院心血管内科,广东省广州市 510515
Keywords: innate immunity; calcific aortic valve disease; inflammation
From: Chinese Journal of Arteriosclerosis 2024;32(6):461-465
CountryChina
Language:Chinese
Abstract: Calcific aortic valve disease(CAVD)is the most common disease affecting the heart valves,character-ized by thickening,fibrosis,and mineralization of the aortic valve leaflets.Currently,there is no effective pharmacologi-cal treatment.Aortic valve calcification is a complex and multifactorial process involving valve inflammation,fibrosis,calcification,valve thickening and outflow tract obstruction.The exact pathophysiological mechanisms of CAVD are not fully understood,but many studies have suggested that innate immune cells play a key role in the development of aortic valve calcification.This review focuses on the current role of innate immune cells in the development of CAVD.