Advances in the functions of the BASP1 protein in human diseases

VernacularTitle:BASP1功能与人类疾病的研究进展
Author: Xiaoqi WU ^{1
,

2} ; Danling WANG
Author Information

1. 南华大学衡阳医学院基础医学院细胞与遗传研究所,湖南省衡阳市 421001
2. 南华大学衡阳医学院附属长沙中心医院,湖南省长沙市 410004
Keywords: brain abundant membrane attached signal protein 1; intrinsically disordered protein; glycolipid metabolic diseases; tumor
From: Chinese Journal of Arteriosclerosis 2024;32(5):444-450
CountryChina
Language:Chinese
Abstract: Brain abundant membrane attached signal protein 1(BASP1)was first discovered in the rat brain and is primarily enriched in brain,heart,mouth,skin,stomach,kidneys and many other human organs.The BASP1 protein is evolutionarily conserved.It participates in cellular biological processes such as cell signaling,cell migration,apoptosis,and gene transcription as an inherently disordered protein(IDP),and is involved in a series of pathophysiological processes such as neural development,kidney development,and germ cell formation.BASP1 plays a very important func-tion in glucose,lipid metabolism diseases and tumor diseases,and is considered to be a potential disease treatment target and molecular diagnostic marker.