The role of arachidonic acid derivatives in the development of abdominal aortic aneurysm

VernacularTitle:花生四烯酸衍生物在腹主动脉瘤发生发展中的作用
Author: Zhiang JIAO ¹ ; Yueyue CHANG ; Shuo MENG ; Sijing MA ; Zhe WANG ; Jian ZHANG
Author Information

1. 华东理工大学药学院上海市新药设计重点实验室,上海市 200237
Keywords: arachidonic acid; prostaglandin; abdominal aortic aneurysm; inflammatory reaction
From: Chinese Journal of Arteriosclerosis 2024;32(5):437-443
CountryChina
Language:Chinese
Abstract: Abdominal aortic aneurysm(AAA)is a common disease in the elderly,with an increasing incidence rate,easy rupture,high mortality,and no effective drugs to slow down the development of AAA.The pathogenesis of AAA is closely related to extracellular matrix degradation,apoptosis of vascular smooth muscle cells and inflammation.It has been found that arachidonic acid derivatives,especially prostaglandins such as prostaglandin E2(PGE2),prostaglandin D2(PGD2)and thromboxane A2(TXA2),play important roles in the development of AAA.Therefore,this review discusses the mechanism of arachidonic acid derivatives in the development of AAA,as well as the latest re-search progress of the drugs,to provide ideas for the treatment of AAA and the discovery of new drug targets.